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1.发明授权THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS 有权Thiazolylphenyl - 苯磺酰胺衍生物和它们作为激酶抑制剂的使用
公开(公告)号：EP2678336B1
公开(公告)日：2016-04-20
申请号：EP12705141.5
申请日：2012-02-21
发明人： PULICI, Maurizio , TRAQUANDI, Gabriella , MARCHIONNI, Chiara , SCOLARO, Alessandra , COLOMBO, Nicoletta
IPC分类号： C07D417/04 , A61K31/44 , A61P35/00
CPC分类号： C07D417/04 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , A61K2300/00
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公开(公告)号：EP2373664B1
公开(公告)日：2013-06-12
申请号：EP09775222.4
申请日：2009-12-17
IPC分类号： C07D513/04 , A61K31/429 , A61K31/542 , A61P35/00
CPC分类号： C07D513/04
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公开(公告)号：EP2324008A1
公开(公告)日：2011-05-25
申请号：EP09780990.9
申请日：2009-07-23
发明人： PULICI, Maurizio , ZUCCOTTO, Fabio , BADARI, Alessandra , NUVOLONI, Stefano , CERVI, Giovanni , TRAQUANDI, Gabriella , BIONDARO, Sonia , TRIFIRO', Paolo , MARCHIONNI, Chiara , MODUGNO, Michele
IPC分类号： C07D401/04 , C07D403/04 , C07D407/14 , C07D409/14 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/635 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D513/14
摘要： 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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4.发明授权SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS 有权3,4-二芳基吡ALS蛋白激酶抑制剂的磺酰胺衍生物
公开(公告)号：EP2528909B1
公开(公告)日：2016-06-22
申请号：EP11701381.3
申请日：2011-01-19
IPC分类号： C07D401/04 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/04 , A61K31/4439
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5.发明公开THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS 有权Thiazolylphenyl - 苯磺酰胺衍生物和它们作为激酶抑制剂的使用
公开(公告)号：EP2678336A1
公开(公告)日：2014-01-01
申请号：EP12705141.5
申请日：2012-02-21
发明人： PULICI, Maurizio , TRAQUANDI, Gabriella , MARCHIONNI, Chiara , SCOLARO, Alessandra , COLOMBO, Nicoletta
IPC分类号： C07D417/04 , A61K31/44 , A61P35/00
CPC分类号： C07D417/04 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , A61K2300/00
摘要： Thiazolylphenyl-benzenesulfonamido derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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公开(公告)号：EP2324008B1
公开(公告)日：2012-05-09
申请号：EP09780990.9
申请日：2009-07-23
发明人： PULICI, Maurizio , ZUCCOTTO, Fabio , BADARI, Alessandra , NUVOLONI, Stefano , CERVI, Giovanni , TRAQUANDI, Gabriella , BIONDARO, Sonia , TRIFIRO', Paolo , MARCHIONNI, Chiara , MODUGNO, Michele
IPC分类号： C07D401/04 , C07D403/04 , C07D407/14 , C07D409/14 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/635 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D513/14
摘要： 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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公开(公告)号：EP3472165A1
公开(公告)日：2019-04-24
申请号：EP17732075.1
申请日：2017-06-19
IPC分类号： C07D487/04 , C07D513/04 , A61P35/00 , A61K31/519 , A61K31/4365
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8.发明公开DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS 有权PYRAZOLPHENYL - 苯磺酰胺化合物的衍生物及其作为抗肿瘤物质
公开(公告)号：EP2601185A1
公开(公告)日：2013-06-12
申请号：EP11738731.6
申请日：2011-08-02
发明人： PULICI, Maurizio , MARCHIONNI, Chiara , TRAQUANDI, Gabriella , SCOLARO, Alessandra , DONATI, Daniele
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D451/04 , C07D471/04 , A61P35/00 , A61K31/4439
CPC分类号： A61K31/4439 , A61K31/437 , A61K31/4545 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D451/04 , C07D471/04
摘要： Substituted pyrazolophenyl-benzenesulfonamide compounds of formula (I) are described, wherein m, R1, R2, R3, and R4 are defined in the description, which modulate the activity of protein kinases, These compounds find utility in treating diseases caused by deregulated protein kinase activity, such as cancer and cell proliferative disorders.
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9.发明公开SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权取代PYRIMIDINYLPYRROLOPYRIDINONDERIVATE，工艺及其使用AS激酶抑制剂和及其
公开(公告)号：EP2443117A1
公开(公告)日：2012-04-25
申请号：EP10725144.9
申请日：2010-06-11
发明人： MARCHIONNI, Chiara , ZUCCOTTO, Fabio , BADARI, Alessandra , ANGIOLINI, Mauro , CARENZI, Davide , CALDARELLI, Marina , PULICI, Maurizio
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61N5/00
摘要： Pyrimidinylpyrrolopyridinone derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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10.发明授权1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权-1H-噻吩并[2,3-C] -PYRAZOLVERBINDUNGEN适用作为激酶抑制剂的
公开(公告)号：EP1904503B1
公开(公告)日：2013-11-06
申请号：EP06764123.3
申请日：2006-07-10
发明人： MOLL, Juergen , FANCELLI, Daniele , BANDIERA, Tiziano , QUARTIERI, Francesca , PULICI, Maurizio
IPC分类号： C07D495/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D495/04
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