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12 条记录 (耗时 0.02 秒)

    SUBSTITUTED 5,12-DIAZA-BENZOANTHRACENE ANALOGUES
    1.
    发明公开
    SUBSTITUTED 5,12-DIAZA-BENZOANTHRACENE ANALOGUES 审中-公开
    取代的5,12-二氮杂 - 苯并蒽类似物

    公开(公告)号：EP1723145A2

    公开(公告)日：2006-11-22

    申请号：EP05729389.6

    申请日：2005-03-11

    申请人： NEUROGEN CORPORATION

    发明人： CALDWELL, Timothy, M. ,  HODGETTS, Kevin, J. ,  HUTCHISON, Alan

    IPC分类号： C07D471/14 ,  A61K31/44

    CPC分类号： C07D498/14 ,  C07D471/12 ,  C07D471/14 ,  C07D491/22 ,  C07D498/04

    摘要： Substituted 5,12-diaza-benzoanthracene analogues are provided, of the Formula (I) wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

    摘要翻译： 提供式（I）的取代的5,12-二氮杂 - 苯并蒽类似物，其中变量如本文所述。 此类化合物是可用于体内或体外调节特定受体活性的配体，并且特别用于治疗与人，家养伴侣动物和家畜动物中的病理性受体激活相关的病症。 提供了用于使用这些化合物来治疗此类病症的药物组合物和方法，以及使用这些配体用于受体定位研究的方法。

    SUBSTITUTED AZASPIRO DERIVATIVES
    4.
    发明公开
    SUBSTITUTED AZASPIRO DERIVATIVES 审中-公开
    取代螺衍生物

    公开(公告)号：EP2021004A2

    公开(公告)日：2009-02-11

    申请号：EP07756232.0

    申请日：2007-05-08

    申请人： NEUROGEN CORPORATION

    发明人： XU, Yuelian ,  CALDWELL, Timothy, M. ,  XIE, Linghong ,  CHENARD, Bertrand, L.

    IPC分类号： A61K31/438

    CPC分类号： C07D471/10 ,  C07D221/20 ,  C07D401/12

    摘要： Substituted azaspiro derivatives of the Formula (I) are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

    SUBSTITUTED PYRIDAZINYL-AND PYRIMIDINYL-QUINOLIN-4-YLAMINE ANALOGUES
    5.
    发明公开
    SUBSTITUTED PYRIDAZINYL-AND PYRIMIDINYL-QUINOLIN-4-YLAMINE ANALOGUES 审中-公开
    替代吡啶并嘧啶-4-磺酰胺

    公开(公告)号：EP1841430A2

    公开(公告)日：2007-10-10

    申请号：EP06719649.3

    申请日：2006-01-25

    申请人： NEUROGEN CORPORATION

    发明人： CALDWELL, Timothy, M. ,  CHENARD, Bertrand, L. ,  HODGETTS, Kevin, J.

    IPC分类号： A61K31/4985 ,  C07D487/04

    CPC分类号： C07D471/04

    摘要： Substituted pyridazinyl- and pyrimidinyl-quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

    SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES
    6.
    发明公开
    SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES 审中-公开
    取代的喹啉-4-胺类似物

    公开(公告)号：EP1644372A2

    公开(公告)日：2006-04-12

    申请号：EP04779026.6

    申请日：2004-07-14

    申请人： NEUROGEN CORPORATION

    发明人： BAKTHAVATCHALAM, Rajagopal ,  CALDWELL, Timothy, M. ,  CHENARD, Bertrand, L. ,  DE LOMBAERT, Stéphane ,  HODGETTS, Kevin, J.

    IPC分类号： C07D471/04 ,  C07D401/04 ,  C07D491/04

    CPC分类号： C07D401/04 ,  C07D215/44 ,  C07D471/04 ,  C07D491/14

    摘要： Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

    摘要翻译： 提供了取代的喹啉-4-基胺类似物。 此类化合物是可用于体内或体外调节特定受体活性的配体，并且特别用于治疗与人，家养伴侣动物和家畜动物中的病理性受体激活相关的病症。 提供了使用它们治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。