公开(公告)号：EP1871762A2

公开(公告)日：2008-01-02

申请号：EP06750555.2

申请日：2006-04-18

申请人： NEUROGEN CORPORATION

发明人： WHITEHOUSE, Darren ,  HU, Shaojing ,  ZHAO, He ,  GUO, Qin ,  WUSTROW, David ,  HAMMER, Jack ,  MAYNARD, George ,  MAO, Jianmin ,  FRINGLE, Wallace ,  YUAN, Jun ,  LI, Hongbin

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D401/14 ,  C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  C07D405/12 ,  C07D401/12 ,  C07D403/12 ,  C07D417/04 ,  A61K31/497 ,  A61K31/53

CPC分类号： C07D403/14 ,  C07D213/28 ,  C07D213/61 ,  C07D213/74 ,  C07D239/42 ,  C07D239/54 ,  C07D241/12 ,  C07D241/20 ,  C07D241/24 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： Compounds of Formula (I) are provided. In which the variables are as described herein. Such compounds may be used to modulate CBl activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CBl modulation in humans, domesticated companion animals and livestock animals, including appetite disorders, obesity and addictive disorders. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such Iigands for receptor localization studies and various in vitro assays.