公开(公告)号：EP1068193A1

公开(公告)日：2001-01-17

申请号：EP99909657.1

申请日：1999-02-26

申请人： NEUROGEN CORPORATION

发明人： KOVER, Renata, X. ,  TERDJANIAN, Silva ,  TRAN, Jennifer ,  THURKAUF, Andrew

IPC分类号： C07D401/06 ,  A61K31/445 ,  C07D295/14 ,  A61K31/495 ,  C07D209/08 ,  C07D215/08 ,  C07D265/36 ,  A61K31/535 ,  C07D279/16 ,  A61K31/54 ,  C07D209/54

CPC分类号： C07D295/15 ,  C07D209/08 ,  C07D209/54 ,  C07D215/08 ,  C07D265/36 ,  C07D279/16 ,  C07D401/06

摘要： Disclosed are compounds of formula (I) or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH; R1, R2 and R3 represents hydrogen, halogen, hydroxy, alkoxy, alkyl, trifluoromethyl or trifluoromethoxy; R4 and R4' represent hydrogen, alkyl or form a ring with the atom to which they are attached; R5 represents hydrogen, alkyl, alkoxy, or alkylthio, and R6 represents hydrogen or alkyl; or R5 and R6 form a ring together with the atoms to which they are attached; and R7, R8, R9, R10 and R11 represent hydrogen or alkyl, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents. Also encompassed within the scope of the invention are intermediates of formulae (VII-a) and (VII-b) wherein X represents oxygen, or sulfur, or CH2, m is zero or an integer of from 1-4, and L is a leaving group.