公开(公告)号：EP1325006A2

公开(公告)日：2003-07-09

申请号：EP01964561.3

申请日：2001-08-06

申请人： NEUROGEN CORPORATION ,  PFIZER INC.

发明人： MAYNARD, George ,  YOHANNES, Daniel ,  YUAN, Jun ,  XIE, Linghong ,  GHOSH, Manuka ,  LUKE, George, P. ,  LIU, Xiaojun ,  NAGEL, Art ,  VINCENT, Lawrence, Albert ,  CURRIE, Kevin, S. ,  WANG, Zhe-Qing ,  LEE, Kyungae

IPC分类号： C07D471/14

CPC分类号： C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D513/04

摘要： Disclosed are heterocyclic compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptor.