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1.发明公开ALBUMIN BINDING SITES FOR EVALUATING DRUG INTERACTIONS AND METHODS OF EVALUATING OR DESIGNING DRUGS BASED ON THEIR ALBUMIN BINDING PROPERTIES 审中-公开白蛋白结合药物相互作用的评价模式和方法进行评估或药物的设计在网站ON及其白蛋白结合特性的基础
公开(公告)号：EP1684705A4
公开(公告)日：2008-02-20
申请号：EP04817518
申请日：2004-11-03
发明人： CARTER DANIEL C , HO JOSEPH , WANG ZHONGMIN
IPC分类号： A61K20060101 , G06F17/11 , G06F19/00 , G06F19/16 , G06F19/18
CPC分类号： G01N33/6803 , G01N2333/76 , G01N2333/765 , G01N2500/04 , G06F19/16 , G06F19/706
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2.发明公开ALBUMIN BINDING SITES FOR EVALUATING DRUG INTERACTIONS AND METHODS OF EVALUATING OR DESIGNING DRUGS BASED ON THERIR ALBUMIN BINDING PROPERTIES 审中-公开白蛋白结合点对药物相互作用进行评估或药物的发展及其对白蛋白结合性能的基础上评价模式和方法
公开(公告)号：EP1627323A4
公开(公告)日：2008-04-09
申请号：EP04751438
申请日：2004-05-06
发明人： CARTER DANIEL C , HO JOSEPH , WANG ZHONGMIN
CPC分类号： C07K14/765 , G01N33/68 , G01N33/6845 , G06F19/16 , G06F19/706
摘要： A method is provided for evaluating drug compounds based on their binding properties to human serum albumin wherein structural information at particular albumin binding regions is entered into a computer database and assessed with regard to particular contacting binding residues located in accordance with the invention. The information obtained through the computer database is thus useful in assessing and predicting drug interactions at albumin binding sites. Further, protein fragments including one or more albumin binding sites are provided which can be used in methods of assessing and designing drugs.
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