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    Packing material for liquid chromatography and process for separation and purification of biopolymer by means of the packing material
    3.
    发明公开
    Packing material for liquid chromatography and process for separation and purification of biopolymer by means of the packing material 有权
    用包装材料的液相色谱，和通过使用填充材料进行分离和生物聚合物的纯化方法

    公开(公告)号：EP2198954A2

    公开(公告)日：2010-06-23

    申请号：EP09179815.7

    申请日：2009-12-18

    申请人： TOSOH CORPORATION

    发明人： Komiya, Katsuo ,  Nakamura, Koji

    IPC分类号： B01J20/32 ,  B01J20/287 ,  B01J20/289 ,  B01D15/32

    CPC分类号： B01J20/3255 ,  B01D15/327 ,  B01J20/287 ,  B01J20/289 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253

    摘要： To provide a novel packing material for liquid chromatography capable of separating and purifying, or collecting and recovering, a biopolymer such as a protein or a peptide by adsorption and desorption by a pH change without being influenced by the isoelectric point of the protein or by the salt concentration in a solvent in which the biopolymer such as the protein is dissolved, and to provide a process for concentrating and recovering a desired biopolymer such as a protein or a peptide from a large amount of dilute cell culture solution by means of such a packing material.
    Separation and purification, or collection and recovery, of a biopolymer, is carried out by liquid chromatography by means of a packing material for liquid chromatography comprising a base matrix and a ligand immobilized to the base matrix, wherein the base matrix is a hydrophilic base matrix having alcoholic hydroxy groups on its surface, the ligand is at least one ligand selected from the group consisting of an α-amino acid represented by the following formula (1):

             RCH(NH 2 )COOH     (1)

    wherein R is an aromatic group or a C 5-7 non-ionic aliphatic group, and an aminomethyl benzoic acid, and the ligand is immobilized to the base matrix by an amide bond or an urethane bond via the amino group contained in the compound represented by the formula (1).

    摘要翻译： 以提供用于液相色谱的新颖的包装材料，其能够分离和纯化，或收集和回收，生物聚合物的：如蛋白质或通过吸附和解吸通过pH改变而不受蛋白质或由等电点的影响的肽 在溶剂中盐的浓度，其中所述生物聚合物：如蛋白质或从大量的稀细胞培养液中，借助于寻求填料的肽：如蛋白质溶解，并用于浓缩和回收期望的生物聚合物提供的处理 材料。 分离和纯化，或收集和回收，生物聚合物，进行通过液相色谱通过液相色谱法，其包括基础基质和固定化到基矩阵的配体的包装材料的手段，worin基础基质是亲水性基矩阵 其表面上具有醇羟基，配体是选自由下式（1）表示的氨基酸±中选择的至少一种配体：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ ƒRCH（NH 2）COOH€ƒ€ƒ€ƒ€ƒ€ƒ（1）worin R是芳族基或C 5-7非离子脂族基团，并且在氨甲基苯甲酸，和配体被固定到 基矩阵通​​过在酰胺键或氨基甲酸酯键在经由包含在由式（1）表示的化合物中的氨基。

    Cholesterol-lowering agents
    4.
    发明公开
    Cholesterol-lowering agents 失效
    胆固醇降低剂

    公开(公告)号：EP0334673A3

    公开(公告)日：1991-01-23

    申请号：EP89302969.4

    申请日：1989-03-23

    申请人： TAISHO PHARMACEUTICAL CO. LTD ,  Tosoh Corporation

    发明人： Asami, Yumiko ,  Komiya, Katsuo ,  Sasaki, Hiroo ,  Aihara, Hironaka

    IPC分类号： A61K31/785

    CPC分类号： A61K31/785 ,  A61K31/74 ,  C08L25/18

    摘要： Cholesterol-lowering agents comprise an anion exchange resin comprising:
    60 to 95 mole% of monomer units of the formula
    (in which X is a halogen atom);
    0 to 25 mole% of monomer units of the formula:
    (in which R¹, R² and R³ are the same or are different and each is a hydrogen atom or a lower alkyl or benzyl group and X has the meaning defined above);
    0 to 30 mole % of monomer units of the formula:
    (in which R⁴ is a hydrogen atom or a lower alkyl or hydroxymethyl group); and
    1 to 6 mole % of monomer units of the formula:

    Packing material for liquid chromatography
    8.
    发明公开
    Packing material for liquid chromatography 失效
    PackungsmaterialfürFlüssigkeitschromatographie。

    公开(公告)号：EP0270095A2

    公开(公告)日：1988-06-08

    申请号：EP87117825.7

    申请日：1987-12-02

    申请人： Tosoh Corporation

    发明人： Kitayama, Ryuichi ,  Komiya, Katsuo ,  Kato, Yoshio

    IPC分类号： B01J20/32 ,  C07B57/00

    CPC分类号： B01J20/286 ,  B01J20/28004 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3221 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3259 ,  B01J20/3261 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2996

    摘要： A packing material for liquid chromatography is dis­closed, which comprises an optically active compound having the formula I:
    wherein Ar is a phenyl group, an α-naphthyl group or a β-naphthyl group, R₁ is an alkyl group having from 1 to 4 carbon atoms, a phenyl group or a 3,5-dinitrophenyl group, R₂ is an alkyl group having from 1 to 4 carbon atoms, * indicates an asymmetric carbon atom and n is an integer of 2 or 3, as a stationary phase. Furthermore, processes for the production of the compounds of formula I and of said packing material are disclosed.

    摘要翻译： 公开了用于液相色谱的包装材料，其包含具有式I的光学活性化合物：其中Ar是苯基，α-萘基或β-萘基，R 1是具有1个 至4个碳原子，苯基或3,5-二硝基苯基，R 2为具有1至4个碳原子的烷基，*表示不对称碳原子，n表示2或3的整数，作为固定相 。 此外，公开了制备式I化合物和所述包装材料的方法。

    Process for production of partially hydrophilized porous adsorbents
    9.
    发明公开
    Process for production of partially hydrophilized porous adsorbents 审中-公开
    Verfahren zur Herstellung von teilweise hydrophilisierten Adsorptionsmitteln

    公开(公告)号：EP1291080A3

    公开(公告)日：2004-05-19

    申请号：EP02019844.6

    申请日：2002-09-09

    申请人： Tosoh Corporation

    发明人： Nakamura, Koji ,  Komiya, Katsuo ,  Fujii, Satoshi

    IPC分类号： B01J20/32 ,  B01J20/26

    CPC分类号： B01J20/261 ,  B01J20/26 ,  B01J20/265 ,  B01J20/267 ,  B01J20/321 ,  B01J20/3248 ,  B01J20/3285

    摘要： A process for production of a partially hydrophilized absorbent is described, which comprises using, as a starting material, porous particles made of an organic compound having properties such that they are shrunk in a solvent containing water as a major component and swollen in a solvent containing an organic solvent as a major component; newly introducing functional groups to react with any one compound selected from the group consisting of compounds containing hydroxyl, amino, carboxyl, halogen or epoxy group in a solvent containing an organic solvent as a major component; and then reacting with a compound containing alcoholic OH group in a solvent containing water as a major component to immobilize the compound containing alcoholic OH group on the outer surfaces of the particles.

    摘要翻译： 描述了一种生产部分亲水化的吸收剂的方法，其包括使用由有机化合物制成的多孔颗粒作为原料，其特征在于它们在含水作为主要成分的溶剂中收缩并在含有 有机溶剂为主要成分; 新引入的官能团与含有羟基，氨基，羧基，卤素或环氧基的化合物中选择的任何一种化合物在含有有机溶剂作为主要成分的溶剂中反应; 然后与含有醇OH基团的化合物在含水的溶剂中作为主要成分进行反应，以将含有醇基OH基团的化合物固定在颗粒的外表面上。

    Process for production of partially hydrophilized porous adsorbents
    10.
    发明公开
    Process for production of partially hydrophilized porous adsorbents 审中-公开
    一种用于部分地亲水化的吸附剂的制备方法

    公开(公告)号：EP1291080A2

    公开(公告)日：2003-03-12

    申请号：EP02019844.6

    申请日：2002-09-09

    申请人： Tosoh Corporation

    发明人： Nakamura, Koji ,  Komiya, Katsuo ,  Fujii, Satoshi

    IPC分类号： B01J20/32

    CPC分类号： B01J20/261 ,  B01J20/26 ,  B01J20/265 ,  B01J20/267 ,  B01J20/321 ,  B01J20/3248 ,  B01J20/3285

    摘要： A process for production of a partially hydrophilized absorbent is described, which comprises using, as a starting material, porous particles made of an organic compound having properties such that they are shrunk in a solvent containing water as a major component and swollen in a solvent containing an organic solvent as a major component; newly introducing functional groups to react with any one compound selected from the group consisting of compounds containing hydroxyl, amino, carboxyl, halogen or epoxy group in a solvent containing an organic solvent as a major component; and then reacting with a compound containing alcoholic OH group in a solvent containing water as a major component to immobilize the compound containing alcoholic OH group on the outer surfaces of the particles.