公开(公告)号：EP0339970A2

公开(公告)日：1989-11-02

申请号：EP89304158.2

申请日：1989-04-26

申请人： NIPPON SHOKUBAI CO., LTD.

发明人： Ueno, Tsunemasa ,  Yamamoto, Koichi ,  Kitano, Masao ,  Morimoto, Yutaka

IPC分类号： C07D233/64

CPC分类号： C07D233/64 ,  Y02P20/582

摘要： 4-Methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole can be effectively produced by the causing 4-methylimidazole or a salt thereof to react with

(a) a formaldehyde adduct of cysteamine,
(b) 2-aminoethanethiol sulphuric acid and formaldehyde or a formaldehyde oligomer, or
(c) thiazolidine or a salt thereof, in the presence of a mineral acid.

A portion of reaction liquid is withdrawn from the reaction system while maintaining the molar concentration of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole in the reaction system at a level not exceeding 70 mol% based on the total number of mols of 4-methylimidazole and 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole. A liquid containing 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole, is then separated from the reaction liquid and the remainder is recycled into the reaction system.

摘要翻译： 4-甲基-5 - [（2-氨基乙基）硫甲基] - 咪唑可以通过使4-甲基咪唑或其盐与（a）半胱胺的甲醛加合物，（b）2-氨基乙硫醇硫酸 酸和甲醛或甲醛低聚物，或（c）噻唑烷或其盐在无机酸存在下进行。 将反应液体的一部分从反应体系中取出，同时将反应体系中4-甲基-5 - [（2-氨基乙基） - 硫甲基] - 咪唑的摩尔浓度保持在不超过70mol％的水平 4-甲基咪唑和4-甲基-5 - [（2-氨基乙基）硫代甲基] - 咪唑的摩尔数。 然后将含有4-甲基-5 - [（2-氨基乙基） - 硫代甲基] - 咪唑的液体与反应液体分离，其余物质循环进入反应体系。

公开(公告)号：EP0387567A3

公开(公告)日：1991-01-02

申请号：EP90103596.4

申请日：1990-02-23

申请人： NIPPON SHOKUBAI CO., LTD.

发明人： Takahashi, Kazutomo ,  Yamamoto, Koichi ,  Kodama, Kazuo ,  Suzuki, Seiichi ,  Tazaki, Takashi ,  Morimoto, Yutaka ,  Nishibayashi, Hideyuki

IPC分类号： C08F8/30 ,  C08F8/44

CPC分类号： C02F1/54 ,  C08F8/44 ,  C08F8/32 ,  C08F120/06 ,  C08F220/06

摘要： An amphoteric polyelectrolite represented by the general formula:
wherein R¹, R², R³ and R⁴ are H or alkyl, R⁵ is H, alkyl or w-OH substituted alkyl, HY is monobasic acid, and Z is amide.

公开(公告)号：EP0387028A3

公开(公告)日：1991-03-06

申请号：EP90302422.2

申请日：1990-03-07

申请人： NIPPON SHOKUBAI CO., LTD.

发明人： Kitano, Masao ,  Yagisawa, Mitsuaki ,  Morimoto, Yutaka

IPC分类号： C07D277/14

CPC分类号： C07D277/14

摘要： A method for the production of a 1,3-thiazolidin-2-­one represented by the general formula II:
wherein R¹, R², R³, and R⁴ are independently hydrogen atom or a lower alkyl group, which method comprises causing a 1,3-thiazolidine represented by the general formula I:
wherein R¹, R², R³, R⁴, R⁵, and R⁶ are independently hydrogen atom or a lower alkyl group to react with urea.

公开(公告)号：EP0387567A2

公开(公告)日：1990-09-19

申请号：EP90103596.4

申请日：1990-02-23

申请人： NIPPON SHOKUBAI CO., LTD.

发明人： Takahashi, Kazutomo ,  Yamamoto, Koichi ,  Kodama, Kazuo ,  Suzuki, Seiichi ,  Tazaki, Takashi ,  Morimoto, Yutaka ,  Nishibayashi, Hideyuki

IPC分类号： C08F8/30 ,  C08F8/44

CPC分类号： C02F1/54 ,  C08F8/44 ,  C08F8/32 ,  C08F120/06 ,  C08F220/06

摘要： An amphoteric polyelectrolite represented by the general formula:
wherein R¹, R², R³ and R⁴ are H or alkyl, R⁵ is H, alkyl or w-OH substituted alkyl, HY is monobasic acid, and Z is amide.

摘要翻译： 由以下通式表示的两性聚电解质：其中R 1，R 2，R 3和R 4是H或烷基，R 5是H，烷基或w-OH取代的 烷基，HY是一元酸，Z是酰胺。

公开(公告)号：EP0269315A2

公开(公告)日：1988-06-01

申请号：EP87309967.5

申请日：1987-11-11

申请人： NIPPON SHOKUBAI CO., LTD.

发明人： Ueno, Tsunemasa ,  Morimoto, Yutaka

IPC分类号： C07D307/54

CPC分类号： C07D307/52

摘要： A process for producing 2-[[[5-(dialkylamino)alkyl-2-­furanyl]methyl]thio]-ethane amine comprises reacting cysteamine or cysteamine hydrochloride containing free hydrogen chloride with 5-(dialkylamino)alkyl furfuryl alcohol. The product can be obtained in a high yield by carrying out the reaction at a temperature of from 30° to 80°C.

摘要翻译： 制备2 - [[[5-（二烷基氨基）烷基-2-呋喃基]甲基]硫代]乙烷胺的方法包括使含有游离氯化氢的半胱胺或半胱胺盐酸盐与5-（二烷基氨基）烷基糠醇反应。 通过在30〜80℃的温度下进行反应，可以高产率地得到该产物。

公开(公告)号：EP0339970A3

公开(公告)日：1992-04-15

申请号：EP89304158.2

申请日：1989-04-26

申请人： NIPPON SHOKUBAI CO., LTD.

发明人： Ueno, Tsunemasa ,  Yamamoto, Koichi ,  Kitano, Masao ,  Morimoto, Yutaka

IPC分类号： C07D233/64

CPC分类号： C07D233/64 ,  Y02P20/582

摘要： 4-Methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole can be effectively produced by the causing 4-methylimidazole or a salt thereof to react with
(a) a formaldehyde adduct of cysteamine, (b) 2-aminoethanethiol sulphuric acid and formaldehyde or a formaldehyde oligomer, or (c) thiazolidine or a salt thereof, in the presence of a mineral acid. A portion of reaction liquid is withdrawn from the reaction system while maintaining the molar concentration of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole in the reaction system at a level not exceeding 70 mol% based on the total number of mols of 4-methylimidazole and 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole. A liquid containing 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole, is then separated from the reaction liquid and the remainder is recycled into the reaction system.

公开(公告)号：EP0387028A2

公开(公告)日：1990-09-12

申请号：EP90302422.2

申请日：1990-03-07

申请人： NIPPON SHOKUBAI CO., LTD.

发明人： Kitano, Masao ,  Yagisawa, Mitsuaki ,  Morimoto, Yutaka

IPC分类号： C07D277/14

CPC分类号： C07D277/14

摘要： A method for the production of a 1,3-thiazolidin-2-­one represented by the general formula II:
wherein R¹, R², R³, and R⁴ are independently hydrogen atom or a lower alkyl group, which method comprises causing a 1,3-thiazolidine represented by the general formula I:
wherein R¹, R², R³, R⁴, R⁵, and R⁶ are independently hydrogen atom or a lower alkyl group to react with urea.

摘要翻译： 制备由通式II表示的1,3-噻唑烷-2-酮的方法：其中R 1，R 2，R 3和R 4独立地是氢 原子或低级烷基，该方法包括引入由通式I表示的1,3-噻唑烷：其中R 1，R 2，R 3，R 4，R 4， 5>，R 6独立地为氢原子或与脲反应的低级烷基。