公开(公告)号：EP1352964A1

公开(公告)日：2003-10-15

申请号：EP00985832.5

申请日：2000-12-22

申请人： NIPPON SODA CO., LTD.

发明人： HAYAKAWA, Koichi ,  KOBAYASHI, Yoichi ,  YOKOYAMA, Masahiro

IPC分类号： C12P7/42 ,  C12P11/00 ,  C12P13/02

CPC分类号： C12P13/02 ,  C12P1/00

摘要： An industrially advantageous process for producing a substance wherein the production speed of a reaction product in a reaction with the use of a microbial catalyst can be maintained at a constant level over a long period of time. In a reaction with the use of a microbial catalyst (for example, resting cells of an arthrobacter capable of converting a-hydroxynitriles into the corresponding a-hydroxy acid amides or a-hydroxy acid ammonium salts), the substance is produced at a constant speed by adding the substrate at a constant speed, regulating the concentration of the microbial catalyst in the liquid reaction mixture at a constant level and controlling the temperature so as to rise the reaction temperature at the point that the enzymatic activity of the microbial catalyst is lowered in the course of the reaction so as to maintain the reaction speed at a constant level.

摘要翻译： 的制造worin与使用的微生物催化剂的反应的反应产物的生产速度的物质的工业上有利的方法可以保持在恒定的电平在一段长的时间。 与使用的微生物催化剂的反应（例如，休息能够将一个羟基腈成相应的α-羟基酸的酰胺或α-羟基酸的铵盐的节杆菌的细胞），该物质被以恒定的速度产生 通过以恒定的速度添加底物，在恒定水平调节在液体反应混合物中的微生物催化剂的浓度和控制温度，以便上升，反应温度在点做了微生物催化剂的酶活性以降低 在反应的过程中，从而保持反应速度在恒定的水平。