公开(公告)号：EP2221306A4

公开(公告)日：2010-12-29

申请号：EP08851321

申请日：2008-11-20

申请人： NISSAN CHEMICAL IND LTD ,  TOHOKU TECHNO ARCH CO LTD

发明人： HAMADA TOSHIMASA ,  NAGAHAMA NORIAKI ,  KOZAWA MASAMI ,  IWABUCHI YOSHIHARU ,  SHIBUYA MASATOSHI ,  TOMIZAWA MASAKI ,  SASANO YUSUKE

IPC分类号： C07D451/14 ,  C07B61/00

CPC分类号： C07D451/14

公开(公告)号：EP1775296A4

公开(公告)日：2009-06-03

申请号：EP05765126

申请日：2005-06-24

申请人： NISSAN CHEMICAL IND LTD

发明人： IWABUCHI YOSHIHARU ,  SHIBUYA MASATOSHI ,  TOMIZAWA MASAKI

IPC分类号： C07D471/08

CPC分类号： C07D471/08 ,  B01J31/006 ,  B01J31/0235 ,  B01J31/0237 ,  B01J2231/70 ,  C07C45/29

摘要： An organic oxidation catalyst for alcohols which is environmentally less harmful and with which efficient oxidation can be conducted. The oxidation catalyst for alcohols is a 1-alkyl-2-azadamantan-N-oxyl which has a nitroxyl group incorporated in the adamantane skeleton and was synthesized from as a base material a bicyclic compound obtained by the Grob-type ring-opening reaction of 1,3-adamantanediol. Due to the nitroxyl group on the adamantane skeleton, the α-position hydrogen is stabilized based on Bredt's rule and the stability of the oxoammonium group generated by the oxidation thereof is ensured. Compared to TEMPO, which is a conventional oxidation catalyst, this catalyst is reduced in steric hindrance and is usable in a wide range of reaction fields. Because of this, not only a primary alcohol but a secondary alcohol having a sterically complicated structure, which has been difficult to oxidize with TEMPO, can be oxidized at a high efficiency.