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    Percutaneous absorption preparation
    2.
    发明公开
    Percutaneous absorption preparation 失效
    Zusammensetzung zur perkutan吸收

    公开(公告)号：EP0711551A2

    公开(公告)日：1996-05-15

    申请号：EP95117714.6

    申请日：1995-11-09

    申请人： NITTO DENKO CORPORATION

    发明人： Akemi, Hitoshi ,  Muraoka, Takateru ,  Higashio, Kazuhiro ,  Suzuki, Yutaka ,  Otsuka, Saburo

    IPC分类号： A61K9/70 ,  A61K47/14

    CPC分类号： A61K9/7061 ,  A61K9/0014 ,  A61K47/14

    摘要： This invention provides a percutaneous absorption preparation for use in the percutaneous administration of drugs for percutaneous absorption into the living body for the purpose of preventing or treating various diseases, which has excellent adhesion to the skin and does not cause pain and damage to corneum when peeled off. Its pressure-sensitive adhesive layer contains an acrylic copolymer comprising a (meth)acrylic acid alkyl ester and a functional monomer as essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms and a drug for percutaneous absorption, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of the drug from the preparation is improved and the area of the preparation can be miniaturized.

    摘要翻译： 本发明提供一种经皮吸收制剂，用于经皮给药的药物，用于经皮吸收到生物体中，用于预防或治疗各种疾病，其对皮肤的粘附性优异，并且在剥离时不会引起疼痛和对角质的损伤 关闭。 其压敏粘合剂层含有包含（甲基）丙烯酸烷基酯和功能性单体作为必要组分的丙烯酸共聚物，具有特定碳原子数的脂肪酸酯，具有特定数目碳原子的单酸甘油酯和 用于经皮吸收的药物，并且压敏粘合剂层交联。 由于通过包含单甘油酯改善其皮肤粘合性，因此制剂中的药物释放得到改善，制剂的面积可以小型化。

    Package structure of drug-containing pressure-sensitive adhesive sheet
    3.
    发明公开
    Package structure of drug-containing pressure-sensitive adhesive sheet 失效
    Verpackungsstruktur eines arzneistoffhaltigen Haftklebepflasters。

    公开(公告)号：EP0635262A2

    公开(公告)日：1995-01-25

    申请号：EP94110831.8

    申请日：1994-07-12

    申请人： NITTO DENKO CORPORATION

    发明人： Akemi, Hitoshi ,  Kinoshita, Takashi ,  Muraoka, Takateru ,  Higashio, Kazuhiro ,  Otsuka, Saburo

    IPC分类号： A61K9/70

    CPC分类号： A61F15/001 ,  A61B2050/002 ,  A61B2050/314 ,  A61F2013/00646 ,  A61F2013/00897 ,  A61K9/703 ,  A61K9/7038

    摘要： A package structure, in which a drug-containing pressure-sensitive adhesive sheet comprising a support, a drug-containing pressure-sensitive adhesive layer, and a separator in this order is packaged and sealed in a packaging material, is disclosed, wherein unevenness is provided on at least one of the surface of the support on the side in contact with the inside of the packaging material, the surface of the separator on the side in contact with the inside of the packaging material, and the inside surface of the packaging material. The unevenness reduces the contact area between the packaging material and the sheet so that an adhesive, a plasticizer or any liquid component of the adhesive layer is prevented from adhering to the inside of the packaging material. Therefore, the sheet can easily be taken out of unit package on use.

    摘要翻译： 公开了一种包装结构，其中包含载体，含药物的压敏粘合剂层和隔膜的药物含压敏粘合片依次包装并密封在包装材料中，其中不均匀性为 设置在与包装材料的内部接触的一侧的支撑体的表面中的至少一个上，隔板的与包装材料的内部接触的一侧的表面和包装材料的内表面 。 不均匀性降低了包装材料和片材之间的接触面积，从而防止粘合剂，增塑剂或粘合剂层的任何液体成分粘附到包装材料的内部。 因此，在使用时，可以容易地将纸张从单元包装中取出。

    Percutaneous absorption preparation
    5.
    发明公开
    Percutaneous absorption preparation 失效
    经皮吸收制剂

    公开(公告)号：EP0711551A3

    公开(公告)日：1996-05-22

    申请号：EP95117714.6

    申请日：1995-11-09

    申请人： NITTO DENKO CORPORATION

    发明人： Akemi, Hitoshi ,  Muraoka, Takateru ,  Higashio, Kazuhiro ,  Suzuki, Yutaka ,  Otsuka, Saburo

    IPC分类号： A61K9/70 ,  A61K47/14

    CPC分类号： A61K9/7061 ,  A61K9/0014 ,  A61K47/14

    摘要： This invention provides a percutaneous absorption preparation for use in the percutaneous administration of drugs for percutaneous absorption into the living body for the purpose of preventing or treating various diseases, which has excellent adhesion to the skin and does not cause pain and damage to corneum when peeled off. Its pressure-sensitive adhesive layer contains an acrylic copolymer comprising a (meth)acrylic acid alkyl ester and a functional monomer as essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms and a drug for percutaneous absorption, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of the drug from the preparation is improved and the area of the preparation can be miniaturized.

    摘要翻译： 本发明提供一种经皮吸收制剂，其用于经皮吸收经皮吸收到生物体内的药物，用于预防或治疗各种疾病，这些疾病对皮肤具有优异的粘附性并且不会在剥离时引起疼痛和角质层损伤 关闭。 其压敏胶粘剂层含有丙烯酸共聚物，该丙烯酸共聚物包含（甲基）丙烯酸烷基酯和官能单体作为必要组分，具有特定碳原子数的脂肪酸酯，具有特定碳原子数的单甘油酯和 用于经皮吸收的药物，并且压敏粘合剂层被交联。 由于通过包含甘油单酯改善了其皮肤粘合性，所以药物从制剂中释放得到改善，并且制剂的面积可以小型化。