公开(公告)号：EP1550675A4

公开(公告)日：2006-01-11

申请号：EP03798560

申请日：2003-09-30

申请人： NOF CORP ,  DAIICHI SEIYAKU CO

发明人： OHHASHI SYUNSUKE ,  KUBO KAZUHIRO ,  ITOH CHIKA ,  YASUKOHCHI TOHRU ,  KIKUCHI H ,  SUZUKI N ,  TAKAHASHI M ,  YAMAUCHI H

IPC分类号： G01R5/16 ,  A61K8/14 ,  A61K8/81 ,  A61K9/127 ,  A61K31/795 ,  A61P35/00 ,  A61Q19/00 ,  C08F8/40 ,  C08L53/00 ,  A61K7/00 ,  A61K45/00 ,  A61K47/32

CPC分类号： C08F8/40 ,  A61K8/14 ,  A61K8/8164 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K31/795 ,  A61Q19/00 ,  C08F220/28 ,  C08F222/06 ,  C08L53/00 ,  C08F222/04 ,  C08L2666/02

摘要： A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) ÄR and R represent hydrogen atom or methyl group, provided that R and R do not simultaneously represent methyl group; R represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R CO and R CO represent an acyl group having 8 to 24 carbon atoms; R represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammoniumÜ wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.