公开(公告)号：EP2142181A1

公开(公告)日：2010-01-13

申请号：EP08735541.8

申请日：2008-03-27

申请人： NOLabs AB

发明人： LINDGREN, Lars ,  MÅRLIND, Linda ,  THORSEN, Rikard

IPC分类号： A61K9/70 ,  A61L15/44 ,  A61K33/00

CPC分类号： A61K9/703 ,  A61F2013/00646 ,  A61K9/7084 ,  A61K33/00 ,  A61L15/44 ,  A61L2300/114 ,  A61L2300/602 ,  A61M35/00

摘要： A topical dermal delivery device, such as a patch, for topical delivery of nitric oxide (NO) to treatment sites of mammals is disclosed. The topical nitric oxide delivery device is provided for arrangement at a treatment site, and comprises a nitric oxide releasing fluid in use of said device, wherein said nitric oxide releasing fluid is at least partly liquid; a reservoir arranged to retain said nitric oxide releasing fluid; and a nitric oxide permeable layer adapted to adhere to said treatment site and adapted to provide an interfacial area for efficient transport of nitric oxide from said nitric oxide releasing fluid to said treatment site; wherein at least said nitric oxide permeable layer is geometrically flexible such that a loss of said interfacial area between said nitric oxide permeable layer and said treatment area is substantially avoided in use of said device, whereby said device is adapted to provide a desired, controllable and consistent delivery of said nitric oxide even under physical deformation of said device from said reservoir to said treatment site while avoiding transport of undesired species from said reservoir to said treatment site.

摘要翻译： 公开了用于将一氧化氮（NO）局部递送至哺乳动物治疗部位的局部皮肤递送装置，例如贴剂。 局部一氧化氮递送装置被提供用于布置在治疗部位，并且包括使用所述装置的一氧化氮释放液，其中所述一氧化氮释放液至少部分为液体; 储存器，其布置成保留所述一氧化氮释放流体; 以及一氧化氮渗透层，其适于粘附到所述治疗部位并且适于提供界面区域以将氧化氮从所述一氧化氮释放流体有效地运输到所述治疗部位; 其中至少所述一氧化氮渗透层在几何上是柔性的，使得所述一氧化氮渗透层和所述处理区域之间的所述界面区域的损失在所述装置的使用中基本上被避免，由此所述装置适于提供期望的，可控制的 即使在所述装置从所述储存器到所述处理部位的物理变形下，所述一氧化氮的一致输送也同时避免不需要的物质从所述储存器输送到所述处理部位。

公开(公告)号：EP2533773A2

公开(公告)日：2012-12-19

申请号：EP11773727.0

申请日：2011-10-21

申请人： NOLabs AB

发明人： STHENGEL, Elisabeth ,  NGO, See Man ,  LINDGREN, Lars

IPC分类号： A61K9/70 ,  A61L15/44

CPC分类号： A61K9/7092 ,  A61L15/44 ,  A61L29/16 ,  A61L2300/114

摘要： Apparatus, methods, and systems for delivering nitric oxide to a disease or cosmetic treatment site involve a nitric oxide (NO) precursor and a reducing agent capable of forming a transient complex with NO contained within a pouch. The NO precursor is separated from the reducing and complexing agent by a removable or breakable barrier. Nitric oxide production and release is activated by breaking or removing the barrier to allow NO precursor to mix with the reducing/complexing agent, which may optionally act as an indicator of NO concentration in a device. NO release from the device is regulated by the ratio of NO precursor to reducing/complexing agent and/or the thickness of a NO permeable membrane located between the compartment and a treatment site.

公开(公告)号：EP2142179A1

公开(公告)日：2010-01-13

申请号：EP07727396.9

申请日：2007-03-27

申请人： NOLabs AB

发明人： LINDGREN, Lars ,  MÅRLIND, Linda ,  THORSEN, Rikard

IPC分类号： A61K9/70 ,  A61L15/44 ,  A61K33/00

CPC分类号： A61K9/703 ,  A61F2013/00646 ,  A61K9/7084 ,  A61K33/00 ,  A61L15/44 ,  A61L2300/114 ,  A61L2300/602 ,  A61M35/00

摘要： A topical dermal delivery device, such as a patch, for topical delivery of nitric oxide (NO) to treatment sites of mammals is disclosed. In an embodiment the patch has three layers; a backing with an activation window, a absorbent core as a reservoir and an NO permeable membrane with an adhesive layer towards the skin. The NO donor is applied into the device as a solution prior to application through the activation window. The window is closed after activation and the lid and backing is non-permeable for NO in order to increase the partial pressure of NO and thus the concentration of dissolved NO. The patch is fixated on the area to be treated with an adhesive layer that also assures sufficient contact throughout the treatment. The generated NO moves within the patch and can escape through the NO permeable membrane towards the area to be treated. Depending on therapy needed, the patch release curve differs and is chosen accordingly.

摘要翻译： 公开了一种用于将一氧化氮（NO）局部递送到哺乳动物的处理部位的局部皮肤递送装置，例如贴片。 在一个实施例中，贴片具有三层; 具有活化窗的背衬，作为储存器的吸收芯和具有朝向皮肤的粘合剂层的NO可渗透膜。 NO供体在通过激活窗口施加之前作为溶液施加到设备中。 激活后窗口关闭，盖子和背衬对于NO是不可渗透的，以增加NO的分压，从而增加溶解的NO的浓度。 该贴片固定在待处理的区域上，该粘合层在整个治疗过程中也保证足够的接触。 所产生的NO在贴片内移动，并且可以通过NO渗透膜向待处理的区域逸出。 根据需要的治疗，补片释放曲线不同，并相应地选择。