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公开(公告)号：EP2118087A1
公开(公告)日：2009-11-18
申请号：EP08729174.6
申请日：2008-02-06
申请人： Novartis AG
发明人： PECCHI, Sabina , NI, Zhi-jie , BURGER, Matthew , WAGMAN, Allan , ATALLAH, Gordana , BARTULIS, Sarah , NG, Simon , PFISTER, Keith, B. , SMITH, Aaron , ZHANG, Yanchen , MERRITT, Hanne , VOLIVA, Charles
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, auutoimmune and cardiovascular diseases.
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2.发明授权6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING 有权6-O-取代的苯并唑和苯并噻唑化合物及抑制CSF-1R信号传导的方法
公开(公告)号：EP2010528B1
公开(公告)日：2017-10-04
申请号：EP07797244.6
申请日：2007-04-18
申请人： Novartis AG
发明人： SUTTON, James, C. , WIESMANN, Marion , WANG, Weibo , LINDVALL, Mika, K. , LAN, Jiong , RAMURTHY, Savithri , SHARMA, Anu , MIEULI, Elizabeth, J. , KLIVANSKY, Liana, M. , LENAHAN, William, P. , KAUFMAN, Susan , YANG, Hong , NG, Simon, C. , PFISTER, Keith , WAGMAN, Allan , SUNG, Victoria , SENDZIK, Martin
IPC分类号： C07D413/12 , C07D417/12 , A61K31/44 , A61P35/00 , A61P19/02 , A61P19/10
CPC分类号： C07D413/12 , C07D417/12
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公开(公告)号：EP2118087B1
公开(公告)日：2012-03-28
申请号：EP08729174.6
申请日：2008-02-06
申请人： Novartis AG
发明人： PECCHI, Sabina , NI, Zhi-jie , BURGER, Matthew , WAGMAN, Allan , ATALLAH, Gordana , BARTULIS, Sarah , NG, Simon , PFISTER, Keith, B. , SMITH, Aaron , ZHANG, Yanchen , MERRITT, Hanne , VOLIVA, Charles
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, auutoimmune and cardiovascular diseases.
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公开(公告)号：EP1984350A1
公开(公告)日：2008-10-29
申请号：EP07716906.8
申请日：2007-01-22
申请人： NOVARTIS AG
发明人： BURGER, Matthew , NI, Zhi-jie , PECCHI, Sabina , ATALLAH, Gordana , BARTULIS, Sarah , FRAZIER, Kelly , SMITH, Aaron , VERHAGEN, Joelle , ZHANG, Yanchen , WAGMAN, Allan , NG, Simon , PFISTER, Keith , POON, Daniel , LOUIE, Alicia , PICK, Teresa , BARSANTI, Paul , IWANOWICZ, Edwin , FANTL, Wendy , HENDRICKSON, Thomas , KNAPP, Mark , MERITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , XIN, Xiahua
IPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof ; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
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公开(公告)号：EP1984350B1
公开(公告)日：2010-08-18
申请号：EP07716906.8
申请日：2007-01-22
申请人： Novartis AG
发明人： BURGER, Matthew , NI, Zhi-jie , PECCHI, Sabina , ATALLAH, Gordana , BARTULIS, Sarah , FRAZIER, Kelly , SMITH, Aaron , VERHAGEN, Joelle , ZHANG, Yanchen , WAGMAN, Allan , NG, Simon , PFISTER, Keith , POON, Daniel , LOUIE, Alicia , PICK, Teresa , BARSANTI, Paul , IWANOWICZ, Edwin , FANTL, Wendy , HENDRICKSON, Thomas , KNAPP, Mark , MERITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , XIN, Xiahua
IPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof ; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
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