专利检索 ap:("NOVO NORDISK A/S" OR "Biostratum, Inc.") AND inv:"MATHIASEN, Ida Stenfeldt" 第 1 页

1.

发明公开
LAMININ-5 GAMMA2-BINDING PEPTIDES, RELATED COMPOSITIONS, AND USE THEREOF 审中-公开
标题翻译：层粘连蛋白5 GAMMA2结合肽，任何相关组合物，及其用途

公开(公告)号：EP1682579A1

公开(公告)日：2006-07-26

申请号：EP04790062.6

申请日：2004-10-28

申请人： NOVO NORDISK A/S , Biostratum, Inc.

发明人： TRYGGVASON, Karl , MATHIASEN, Ida Stenfeldt , PADK R, S ren Berg , TARABYKINA, Svetlana , SALO, Sirpa , BOUTARD, Ariel

IPC分类号： C07K16/18 , A61K39/395 , A61K48/00 , G01N33/574 , A61P35/00

摘要： Peptides that specifically bind the gamma2 chain of laminin-5 and other gamma2-associated proteins; related compositions (e.g., derivatives and variants of such peptides; nucleic acids comprising sequences encoding such peptides; pharmaceutical compositions comprising either of such molecules; etc.); methods of using the same for diagnostic, prophylactic, and therapeutic purposes; and additional new and useful related compositions and methods are provided.

2.

发明公开
LAMININ-5 MODULATORS AND USES THEREOF 审中-公开
标题翻译： 5层粘连蛋白调节剂及其用途

公开(公告)号：EP1694839A2

公开(公告)日：2006-08-30

申请号：EP04803013.4

申请日：2004-12-13

申请人： NOVO NORDISK A/S

发明人： MATHIASEN, Ida Stenfeldt , BAUER, Michael Karl , MÜLLER, Jörn Roland

IPC分类号： C12N15/11 , A61K31/713 , A61K39/395 , A61P35/00 , A61P37/00

CPC分类号： C12N15/1138 , C12N2310/14

摘要： Described herein are methods of treating or preventing various diseases and disorders using modulators of laminin-5. Exemplary diseases and disorders are inflammatory bowel disease, including ulcerative colitis and Crohn's disease, as well as polycystic kidney disease and cancers associated with one or more of the aforementioned conditions. Exemplary laminin-5 modulators include monoclonal antibodies against the laminin-5 gamma2 chain and short interfering RNA (siRNA) sequences against nucleotide sequences encoding the laminin-5 gamma2 chain. Described are also combination treatments based on the administration of a laminin-5 modulator and at least one other therapeutic agent.