公开(公告)号：EP2321272A1

公开(公告)日：2011-05-18

申请号：EP09810900.2

申请日：2009-08-17

申请人： Nabriva Therapeutics AG

发明人： MANG, Rosemarie ,  HEILMAYER, Werner

IPC分类号： C07C323/52 ,  C07D211/60 ,  A61K31/215 ,  A61K31/4458 ,  A61P31/04

CPC分类号： C07C323/52 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D211/60

摘要： Compounds of formula (I), which are 14-
O -{[(optionally substituted hydroxy)cyclohexyl)sulfanyl]acetyl}mutilins further substituted at the cyclohexyl group by an acylated amino group, salts and solvates thereof, pharmaceutical compositions comprising such compounds and their use as a pharmaceutical,
e.g. for the treatment of diseases mediated by microbes and for the treatment of inflammation where microbese are mediating said inflammation.

摘要翻译： 式（I）化合物，其是在环己基上进一步被酰化氨基取代的14-O - {[（任选取代的羟基）环己基）硫烷基]乙酰}木质素，其盐和溶剂合物，包含此类化合物的药物组合物和 它们作为药物的用途，例如 用于治疗由微生物介导的疾病和用于治疗微生物介导所述炎症的炎症。

公开(公告)号：EP2137143B1

公开(公告)日：2011-09-07

申请号：EP08714294.9

申请日：2008-03-19

申请人： Nabriva Therapeutics AG

发明人： MANG, Rosemarie ,  HEILMAYER, Werner ,  BADEGRUBER, Rudolf ,  STRICKMANN, Dirk ,  NOVAK, Rodger ,  FERENCIC, Mathias ,  BULUSU, Atchyuta, Rama, Chandra, Murty

IPC分类号： C07C323/52 ,  A61K31/215 ,  A61P31/00

CPC分类号： A61K31/5375 ,  A61K31/215 ,  A61K31/357 ,  C07C323/52 ,  C07C323/61 ,  C07C2601/14 ,  C07C2603/99 ,  C07D295/096 ,  C07D317/72

摘要： A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m = 0 then R3 is in position 2', and if m = 1 then R3 is on position 1'); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl; R2 is hydrogen or - (C3-6)cycloalkyl, or - unsubstituted (C1-6)alkyl, or - (C1-6)alkyl substituted by one or more of - hydroxy; preferably one or two, - methoxy, - halogen, - (C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e. g. selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or - with the proviso that R3 is bound to 2' R3 represents -O-(CH2)P-O- with p is 2 or 3; R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl.

公开(公告)号：EP2321272B1

公开(公告)日：2016-04-20

申请号：EP09810900.2

申请日：2009-08-17

申请人： Nabriva Therapeutics AG

发明人： MANG, Rosemarie ,  HEILMAYER, Werner

IPC分类号： C07C323/52 ,  C07D211/60 ,  A61K31/215 ,  A61K31/4458 ,  A61P31/04

CPC分类号： C07C323/52 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D211/60

公开(公告)号：EP2137143A1

公开(公告)日：2009-12-30

申请号：EP08714294.9

申请日：2008-03-19

申请人： Nabriva Therapeutics AG

发明人： MANG, Rosemarie ,  HEILMAYER, Werner ,  BADEGRUBER, Rudolf ,  STRICKMANN, Dirk ,  NOVAK, Rodger ,  FERENCIC, Mathias ,  BULUSU, Atchyuta, Rama, Chandra, Murty

IPC分类号： C07C323/52 ,  A61K31/215 ,  A61P31/00

CPC分类号： A61K31/5375 ,  A61K31/215 ,  A61K31/357 ,  C07C323/52 ,  C07C323/61 ,  C07C2601/14 ,  C07C2603/99 ,  C07D295/096 ,  C07D317/72

摘要： A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m = 0 then R3 is in position 2', and if m = 1 then R3 is on position 1'); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl; R2 is hydrogen or - (C3-6)cycloalkyl, or - unsubstituted (C1-6)alkyl, or - (C1-6)alkyl substituted by one or more of - hydroxy; preferably one or two, - methoxy, - halogen, - (C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e. g. selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or - with the proviso that R3 is bound to 2' R3 represents -O-(CH2)P-O- with p is 2 or 3; R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl.

摘要翻译： 其中n为0至4的式（I）化合物; R是乙基或乙烯基; R 1是氢或（C 1-6）烷基，R 2是氢或 - 包括（C 3-6）环烷基或 - 未取代的（C 1-6）烷基或 - （C 1-6）烷基取代的 通过一个或多个羟基; 优选一个或两个， - 卤素， - （C 3-6）环烷基，或R 1是羟基，R 2是甲酰基。