公开(公告)号：EP1200457A2

公开(公告)日：2002-05-02

申请号：EP00946199.7

申请日：2000-07-21

申请人： Naeja Pharmaceutical Inc.

发明人： SINGH, Rajeshwar,Naeja Pharmaceutical Inc ,  ZHOU, Nian,Naeja Pharmaceutical Inc ,  REDDY, Andhe, V., N.,Naeja Pharmaceutical Inc ,  THOMAS, George,Naeja Pharmaceutical Inc ,  DING, Qizhu,Naeja Pharmaceutical Inc ,  KALETA, Jadwiga,Naeja Pharmaceutical Inc ,  MICETICH, Ronald, George,Naeja Pharmaceutical Inc ,  WHITTAKER, Mark,British Biotech Pharma. Ltd.

IPC分类号： C07K5/062 ,  C07K5/065 ,  C07D295/12 ,  A61K38/05 ,  A61K31/5375 ,  A61K31/381 ,  A61P19/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  A61P9/00 ,  A61P25/00

CPC分类号： C07D295/125 ,  A61K38/00 ,  C07D207/14 ,  C07D333/38 ,  C07K5/06043 ,  C07K5/06078

摘要： This invention relates to derivatives of alpha-amino acid amides, to pharmaceutical compositions containing such compounds, and to their use in medicine as inhibitors of cysteine proteases, particularly the cathepsins. A compound of formula (I) is described or a pharmaceutically acceptable salt, hydrate or solvate thereof. Pharmaceutically acceptable salts of the compounds of this invention include the sodium, potassium, magnesium, calcium, hydrogen chloride, tartaric acid, succinic acid, fumaric acid and p-toluenesulfonic acid salts.