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1.发明公开2-OXO-1-AZETIDINE SULFONIC ACID DERIVATIVES AS POTENT BETA-LACTAMASE INHIBITORS 失效2-氧代-1-氮杂环丁烷磺酸衍生物作为β-内酰胺酶抑制剂的研究
公开(公告)号：EP0979229A1
公开(公告)日：2000-02-16
申请号：EP98915027.1
申请日：1998-04-23
发明人： MAITI, Samarendra, N. , SETTI, Eduardo, L. , PHILLIPS, Oludotun, A. , REDDY, Andhe, V., Narender , MICETICH, Ronald, G. , SINGH, Rajeshwar , HIGASHITANI, Fusahiro , KUNUGITA, Chieko , NISHIDA, Koichi , UJI, Tatsuya
IPC分类号： C07D409/14 , A61K31/44 , C07D417/14 , C07D401/14 , C07D413/14
CPC分类号： C07D409/14 , A61K31/44 , A61K31/54 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： This invention relates to novel 2-oxo-1-azetidine sulfonic acid derivatives of formula (I) which are of value for use in combination with β-lactam antibiotics to increase their effectiveness against infections caused by β-lactamase producing bacteria. In said formula, (I) R1 is a 5-membered heterocyclic ring esp. thiophene, 2-amino thiazole. R2 is a moiety containing hydroxypyridone or N-hydroxypyridone.
摘要翻译： 本发明涉及式（I）的新的2-氧代-1-氮杂环丁烷磺酸衍生物，它们与β-内酰胺抗生素联合使用以增加其抗β-内酰胺酶产生细菌引起的感染的效力。 在所述式中，（I）R 1为5元杂环。 噻吩，2-氨基噻唑。 R2是含羟基吡啶酮或N-羟基吡啶酮的部分。
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公开(公告)号：EP1012139A1
公开(公告)日：2000-06-28
申请号：EP98941015.4
申请日：1998-08-28
发明人： SETTI, Eduardo, L. , MAITI, Samarendra, N. , PHILLIPS, Oludotun, A.,Dept. of Pharmaceutical , REDDY, Andhe, V., Narender , MICETICH, Ronald, G. , HIGASHITANI, Fusahiro , KUNUGITA, Chieko , NISHIDA, Koichi , UJI, Tatsuya
IPC分类号： C07D205/085 , A61K31/545 , A61K31/43
CPC分类号： C07D409/12
摘要： Novel 2-oxo-1-azetidine sulfonic acid derivatives which are potent inhibitors of bacterial β-lactamases, particularly against class C β-lactamases. Pharmaceutical compositions contain these compounds, and optionally also a β-lactam antibiotic. The compounds and compositions can be used to inhibit β-lactamase inactivation, and for the treatment of bacterial infections.
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公开(公告)号：EP1012139B1
公开(公告)日：2002-11-13
申请号：EP98941015.4
申请日：1998-08-28
发明人： SETTI, Eduardo, L. , MAITI, Samarendra, N. , PHILLIPS, Oludotun, A., Dept. of Pharmaceutical , REDDY, Andhe, V., Narender , MICETICH, Ronald, G. , HIGASHITANI, Fusahiro , KUNUGITA, Chieko , NISHIDA, Koichi , UJI, Tatsuya
IPC分类号： C07D205/085 , A61K31/545 , A61K31/43
CPC分类号： C07D409/12
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4.发明授权2-OXO-1-AZETIDINE SULFONIC ACID DERIVATIVES AS POTENT BETA-LACTAMASE INHIBITORS 失效2-氧代-1-氮杂环丁烷磺酸衍生物作为β-内酰胺酶抑制剂的研究
公开(公告)号：EP0979229B1
公开(公告)日：2002-10-23
申请号：EP98915027.1
申请日：1998-04-23
发明人： MAITI, Samarendra, N. , SETTI, Eduardo, L. , PHILLIPS, Oludotun, A. , REDDY, Andhe, V., Narender , MICETICH, Ronald, G. , SINGH, Rajeshwar , HIGASHITANI, Fusahiro , KUNUGITA, Chieko , NISHIDA, Koichi , UJI, Tatsuya
IPC分类号： C07D409/14 , A61K31/44 , C07D417/14 , C07D401/14 , C07D413/14
CPC分类号： C07D409/14 , A61K31/44 , A61K31/54 , C07D413/14 , C07D417/14 , A61K2300/00
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