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公开(公告)号：EP3564266A1
公开(公告)日：2019-11-06
申请号：EP17889368.1
申请日：2017-12-29
发明人： FAN, Xiaohu , ZHUANG, Qiuchuan , WANG, Pingyan , YANG, Lei , ZHENG, Xiujun , HAO, Jiaying , LIU, Shaobo
摘要： The present invention discloses a novel chimeric antigen receptor and use thereof. Said novel chimeric antigen receptor consists of a signal peptide, an antigen binding domain, a transmembrane region, and an intracellular signal domain, and comprises a 4-1BB signal peptide and/or a 4-1BB molecular transmembrane region. The present invention separates and purifies nucleic acid sequences of a plurality of chimeric antigen receptors, and provides a chimeric antigen receptor and a CAR-T cell which are specific for a CD19 malignant tumor antigen. In the malignant tumor killing test of hematological cell lines, the ability of immune cells to target and recognize tumor cells is significantly enhanced, and the killing activity against tumor cells is also enhanced.
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