公开(公告)号：EP4257601A1

公开(公告)日：2023-10-11

申请号：EP21903366.9

申请日：2021-12-06

申请人： National Cancer Center ,  Shimadzu Corporation ,  Dai Nippon Toryo Co., Ltd.

发明人： TAMURA, Kenji ,  SUDO, Kazuki ,  MATSUDA, Takahisa ,  YAMAJI, Taiki ,  OKAMOTO, Koji ,  WATANABE, Makoto ,  FUJIMOTO, Hirotaka ,  SATO, Taka-Aki ,  MIYAZAWA, Yuta

IPC分类号： C07K16/18 ,  G01N33/543 ,  G01N33/574 ,  G01N27/62

摘要： Provided is a method of assisting breast cancer diagnosis, comprising: a measuring step for measuring an amount of laminin 5 or laminin β3 in a specimen; and an information-providing step for providing information for breast cancer diagnosis based on the amount of laminin 5 or laminin β3 thus measured. Provided is a test kit for breast cancer comprising an anti-laminin 5 antibody or an anti-laminin β3 antibody.

公开(公告)号：EP4257979A1

公开(公告)日：2023-10-11

申请号：EP21903387.5

申请日：2021-12-07

申请人： Dai Nippon Toryo Co., Ltd. ,  Shimadzu Corporation

发明人： MIYAZAWA ,Yuta ,  FUJIMOTO, Hirotaka ,  WATANABE, Makoto ,  SATO, Taka-Aki

IPC分类号： G01N33/543

摘要： An object of the present invention is to provide a method for detecting particulate substances with a high degree of sensitivity, while suppressing the generation of non-specific signals.
According to the present invention, the generation of non-specific signals in the background can be suppressed by blocking a membrane of a test strip which is used for immunochromatography with a blocking composition comprising a polymer-based blocking agent having, in its side chain, a substituent represented by the following formula:

(wherein R 1 , R 2 , and R 3 are each independently a hydrogen atom, a C 1-6 alkyl group, or a C 1-6 hydroxyalkyl group; and n is an integer of 1 to 4), and having a weight average molecular weight (Mw) of 1 × 10 3 to 1 × 10 7 .

公开(公告)号：EP2063271A1

公开(公告)日：2009-05-27

申请号：EP07807677.5

申请日：2007-09-13

申请人： Shimadzu Corporation ,  National University Corporation Kobe University

发明人： MASUDA, Taro ,  NISHIMURA, Osamu ,  OKUMURA, Katsuhiko ,  OKAMURA, Noboru ,  WATANABE, Makoto

IPC分类号： G01N33/574 ,  C12Q1/34 ,  C12Q1/37 ,  C12Q1/527

CPC分类号： G01N33/57438

摘要： The present invention provides a tumor marker more highly specific to renal cancer. The present invention provides a method for identifying the morbidity of rental cancer. A tumor marker for renal cancer comprising proteins identified from renal cancerous tissue. A method for identifying the morbidity of renal cancer by using the tumor marker for renal cancer. The method comprises measuring the level of the protein in a sample derived from a person of interest who is to be examined to identify the morbidity of renal cancer; and comparing an obtained measured level to a normal level of the protein, wherein an upregulation or a downregulation of the obtained measured level compared to the normal level is used as one of indexes indicating that there is a high possibility that the person of interest has renal cancer.

摘要翻译： 本发明提供了对肾癌更高度特异性的肿瘤标志物。 本发明提供了一种鉴定出租癌症发病率的方法。 包括肾癌组织鉴定的蛋白质的肾癌肿瘤标志物。 一种通过使用肾癌肿瘤标志物鉴定肾癌发病率的方法。 该方法包括测量衍生自待检查者的样品中蛋白质的水平，以鉴定肾癌的发病率; 将获得的测量水平与蛋白质的正常水平进行比较，其中将所获得的测量水平与正常水平相比的上调或下调用作指标之一，表明感兴趣的人有肾脏的可能性很高 癌症。

公开(公告)号：EP2028492A1

公开(公告)日：2009-02-25

申请号：EP07744982.5

申请日：2007-06-05

申请人： Shimadzu Corporation ,  Osaka University

发明人： WATANABE, Makoto ,  NISHIMURA, Osamu ,  MATSUBARA, Toshiya ,  TAKEMASA, Ichiro ,  MONDEN, Morito ,  NAGAI, Katsuya ,  MATSUURA, Nariaki

IPC分类号： G01N33/574

CPC分类号： G01N33/57419

摘要： The present invention provides a tumor marker and a method capable of identifying the morbidity of colon cancer. A tumor marker including a protein identified from a colon cancer tissue. A method for identify the morbidity of colon cancer using the tumor marker. The method includes: measuring the level of the protein in a sample derived from a person of interest who should be examined to identify the morbidity of colon cancer; and comparing the measured level to the normal level of the protein, wherein a higher or lower measured level than the normal level is used as one indicator indicating that there is a high possibility that the person of interest has colon cancer.

摘要翻译： 本发明提供了能够鉴定结肠癌发病率的肿瘤标志物和方法。 包含从结肠癌组织鉴定的蛋白质的肿瘤标志物。 使用肿瘤标志物鉴定结肠癌发病率的方法。 该方法包括：测量来自应该检查的感兴趣的人的样品中蛋白质的水平，以鉴定结肠癌的发病率; 并将测量的水平与蛋白质的正常水平进行比较，其中比正常水平更高或更低的测量水平被用作指示感兴趣的人具有结肠癌的可能性高的一个指标。

公开(公告)号：EP1700114A2

公开(公告)日：2006-09-13

申请号：EP04808028.7

申请日：2004-12-21

申请人： SHIMADZU CORPORATION

发明人： WATANABE, Makoto ,  MATSUO, Eiichi ,  TODA, Chikako ,  NISHIMURA, Osama

IPC分类号： G01N30/88 ,  G01N30/06 ,  G01N30/84

CPC分类号： C07K1/24

摘要： The present invention finds a media that can highly selectively retain proteins or peptides to be enriched/separated, as well as provides a method for selectively enriching/separating proteins or peptides using such a media. A method for enrichment/separation of a protein or a peptide, comprising separating a protein or a peptide containing an amino acid residue with a π electron-containing group by using a media with a π electron-containing group. Preferably, the amino acid residue is a tryptophan residue or a tryptophan residue modified with a sulfenyl compound, and the media is a media with phenyl group.