公开(公告)号：EP3175851A1

公开(公告)日：2017-06-07

申请号：EP14898918.9

申请日：2014-07-28

申请人： National Chung Hsing University

发明人： SU, Hong-Lin ,  CHANG, Chia-Yu ,  HWANG, Shiaw-Min ,  LU, Huai-En ,  HARN, Horng-Jyh ,  LIN, Shinn-Zong ,  LAI, Ping-Shan

IPC分类号： A61K31/365 ,  A61P17/14 ,  A61P25/28

CPC分类号： A61K31/365 ,  A61K8/4973 ,  A61K9/0014 ,  A61K36/23 ,  A61K36/28 ,  A61K2800/74 ,  A61Q7/00

摘要： The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the β-amyloid protein (Aβ) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of Aβ in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered. Furthermore, the method for preparing a pharmaceutical composition containing Bdph comprises preparing the pharmaceutical composition through an organic synthesis reaction, wherein the Bdph is coated with a polymeric material such as F127 by covalent bonding of the polymeric material with the Bdph, thereby achieving the effect of reducing the cytotoxicity of the pharmaceutical composition for an organism.

摘要翻译： 本发明自由圆盘使用丁烯酜的（BDPh），使用相同的方法，和制备含该化合物的药物组合物的方法。 因为BDPh具有促销廷的能力的所述毛发的生长和减少神经细胞的²淀粉样蛋白（安培）的水平，提高受治疗者的健康和外观的功效可以通过有效量BDPh的施用给受试者来实现。 具体而言，BDPh具有预防或治疗神经变性疾病的功效：如阿尔茨海默氏病通过在细胞A²的过度积聚引起的，如在局部用组合物的活性成分，所述BDPh是有效的促销婷头发的生长在现场 其中BDPh施用。 进一步，用于制备含有BDPh包括通过有机合成反应来制备所述药物组合物的药物组合物，worin的BDPh的方法被涂覆有聚合物材料：如通过与BDPh聚合物材料的共价键合，从而实现的效果F127 减少所述药物组合物的细胞毒性在生物体。