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公开(公告)号：EP3238727A1
公开(公告)日：2017-11-01
申请号：EP15872274.4
申请日：2015-12-24
发明人： ISHII, Ken , AOSHI, Taiki , SATO, Hideaki
IPC分类号： A61K31/7088 , A61K9/127 , A61P37/04 , C12N15/09
CPC分类号： C12N15/117 , A61K9/127 , A61K31/7088 , C12N15/09 , C12N2310/17 , C12N2310/315
摘要： Provided are non-aggregating immunostimulatory oligonucleotides. The present invention also provides a delivery agent for an immunostimulatory-oligonucleotide nucleic acid medicine, said delivery agent including a nucleic acid that contains a phosphorothioated nucleotide. According to another aspect, the present invention further provides an oligonucleotide including a bioactive core, and a nucleic acid that contains a phosphorothioated nucleotide. The present invention yet further provides an immunostimulator including the bioactive core of a type A/D, type B/K, or type C immunostimulatory oligonucleotide.
摘要翻译： 提供非聚集性免疫刺激性寡核苷酸。 本发明还提供用于免疫刺激寡核苷酸核酸药物的递送剂，所述递送剂包含含有硫代磷酸化核苷酸的核酸。 根据另一方面，本发明进一步提供了包含生物活性核心的寡核苷酸和含有硫代磷酸化核苷酸的核酸。 本发明还提供了包含A / D型，B / K型或C型免疫刺激性寡核苷酸的生物活性核的免疫刺激剂。
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2.发明公开COMPLEX CONTAINING OLIGONUCLEOTIDE HAVING IMMUNOPOTENTIATING ACTIVITY AND USE THEREOF 审中-公开与免疫激活作用及其用途寡核苷酸复合物
公开(公告)号：EP3048170A1
公开(公告)日：2016-07-27
申请号：EP14846493.6
申请日：2014-09-19
发明人： ISHII, Ken , KOBIYAMA, Kouji , AOSHI, Taiki , TAKESHITA, Fumihiko , KASUYA, Yuji , NIWA, Takako , KOIZUMI, Makoto
IPC分类号： C12N15/09 , A61K31/7125 , A61K31/713 , A61K39/02 , A61K39/12 , A61K39/39 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07H21/04
CPC分类号： C12N15/117 , A61K31/7125 , A61K31/713 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/39 , A61K2039/5252 , A61K2039/55561 , A61K2039/55583 , C07H21/04 , C08B37/0024 , C12N7/00 , C12N2310/17 , C12N2310/315 , C12N2310/351 , C12N2310/3519 , C12N2320/31 , C12N2760/16134 , C12N2760/18534
摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.
摘要翻译： 本发明提供一种脱氧腺苷酸到含有人源化的K型的CpG寡脱氧核苷酸和聚，聚worin的脱氧腺苷酸放置在人源化K型的CpG寡脱氧核苷酸的3“侧的寡脱氧核苷酸。 此外，本发明提供了一种复合物含有上述寡核苷酸和²-1,3-葡聚糖。
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公开(公告)号：EP4253546A2
公开(公告)日：2023-10-04
申请号：EP23176351.7
申请日：2014-09-19
申请人： National Institutes of Biomedical Innovation, Health and Nutrition , Daiichi Sankyo Company, Limited
发明人： ISHII, Ken , KOBIYAMA, Kouji , AOSHI, Taiki , TAKESHITA, Fumihiko , KASUYA, Yuji , NIWA, Takako , KOIZUMI, Makoto
IPC分类号： C12N15/117
摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.
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公开(公告)号：EP3048170B1
公开(公告)日：2019-07-31
申请号：EP14846493.6
申请日：2014-09-19
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公开(公告)号：EP4253546A3
公开(公告)日：2023-12-13
申请号：EP23176351.7
申请日：2014-09-19
申请人： National Institutes of Biomedical Innovation, Health and Nutrition , Daiichi Sankyo Company, Limited
发明人： ISHII, Ken , KOBIYAMA, Kouji , AOSHI, Taiki , TAKESHITA, Fumihiko , KASUYA, Yuji , NIWA, Takako , KOIZUMI, Makoto
IPC分类号： A61P31/04 , A61P31/12 , A61K31/7125 , A61K31/713 , A61K39/02 , A61K39/12 , A61K39/39 , A61P33/00 , A61P35/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07H21/04 , C12N15/09
摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.
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