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    UTILIZATION OF THE FUNCTION OF RARE SUGAR AS PROMOTER FOR THE MIGRATION OF GLUCOKINASE FROM NUCLEUS TO CYTOPLASM
    1.
    发明公开
    UTILIZATION OF THE FUNCTION OF RARE SUGAR AS PROMOTER FOR THE MIGRATION OF GLUCOKINASE FROM NUCLEUS TO CYTOPLASM 审中-公开
    稀有糖的功能的一种手段用来提高核葡糖激酶的迁移关闭进入细胞质

    公开(公告)号：EP2111865A1

    公开(公告)日：2009-10-28

    申请号：EP07739883.2

    申请日：2007-03-27

    申请人： National University Corporation Kagawa University ,  Matsutani Chemical Industry Co., Ltd.

    发明人： TOKUDA, Masaaki ,  IZUMORI, Ken ,  TOYODA, Yukiyasu ,  MIWA, Ichitomo

    IPC分类号： A61K31/7004 ,  A23L1/30 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  C07H3/02

    CPC分类号： A61K31/121 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/7004 ,  C07H3/02

    摘要： Screening for a glucokinase-activating substance among rare sugars and providing a composition for treating disordered conditions in association with glucokinase activity, the composition containing the glucokinase-activating substance as the active ingredient. A promoting agent of glucokinase transfer from nucleus to cytoplasm, the promoting agent containing D-psicose and/or D-tagatose as the active ingredient, or a composition for preventing the onset of disordered conditions in association with glucokinase activity or for therapeutically treating the disordered conditions, which is in a form selected from a group consisting of food additives, food materials, drinks and foods, health drinks and foods, pharmaceutical product and feeds in blend with D-psicose and/or D-tagatose as the active ingredient for use in preventing the onset of disordered conditions in association with glucokinase activity or for therapeutically treating the disordered conditions. The disordered conditions in association with glucokinase activity are selected from impaired glucose tolerance, type 2 diabetes mellitus, insulin resistance, abnormal lipidemia, the metabolic syndrome and obesity. The composition is in a pharmaceutical form, and contains D-psicose and/or D-tagatose together with one or more pharmaceutically acceptable carriers.

    摘要翻译： 筛选稀有糖中葡萄糖激酶活化物质和用于相关联地葡糖激酶活性，将含有葡萄糖激酶活化物质作为有效成分的组合物来治疗无序条件提供的组合物。 甲促销廷从核葡糖激酶转移到细胞质的代理，促销廷剂含有D-阿洛酮糖和/或D-塔格糖作为有效成分的，或用于与葡糖激酶活性或用于治疗性处理无序预防的无序状况的发病相关联的组合物 条件下，所有这些是在从包括食品添加剂，食品材料，饮料和食品，保健饮料和食品，药物产品的选择的形式，并用D-阿洛酮糖和/或D-塔格糖作为使用的活性成分馈送到刺眼 与葡糖激酶活性或用于治疗性处理无序条件防止无序状况的发作相关联。 与葡糖激酶活性相关联的无序条件从葡萄糖耐量降低，2型糖尿病，胰岛素抵抗，血脂异常，代谢综合征和肥胖症。 所述组合物为药物剂型，并含有D-阿洛酮糖和/或D-塔格糖与一种或多种药学上可接受的载体在一起。