公开(公告)号：EP1859818A1

公开(公告)日：2007-11-28

申请号：EP06729069.2

申请日：2006-03-14

申请人： National University Corporation Nara Institute of Science and Technology

发明人： KAMITAKAHARA, M., c/o National University Corp. ,  TANIHARA, M., c/o National University Corp. ,  OHTSUKI, C., c/o National University Corp. ,  OGATA, Shinichi, c/o National University Corp.

IPC分类号： A61L27/00 ,  C07K2/00

CPC分类号： C07K2/00 ,  A61L27/46 ,  C07K5/0815 ,  C07K5/0821 ,  C07K5/1019 ,  C07K5/1021 ,  C07K14/78 ,  C08L89/00

摘要： The present invention aims at providing a biomaterial composite not having risks of pathogen infection and unfavorable side effects such as rejection response. According to the invention, there is provided a biomaterial composite, which comprises a polypeptide and a calcium phosphate compound, said peptide comprising the units of Formulas (I) to (III):

        [-(OC-(CH 2 ) m -CO) p -(Pro-Y-Gly) n -] a      (I)

        [-(OC-(CH 2 ) m -CO) p -(Z) r -] b      (II)

        [-HN-R-NH-] c      (III)

wherein m, p, q, Y, n, Z, r, R, a, b and c are as defined in the specification. The composite of the invention is particularly suitable for an artificial bone due to its high biocompatibility, high endurance and mechanical strength. Further, the invention can provide a process of the composite according to the invention can for preparation of the composite having excellent mechanical characteristics by a simple procedure.

摘要翻译： 本发明的目的在于提供一种不具有病原体感染风险的生物材料复合物和不良副作用，例如排斥反应。 根据本发明，提供了一种生物材料复合物，其包含多肽和磷酸钙化合物，所述肽包含式（I）至（III）的单元：€ƒ€ƒ€ƒ€ƒ€ ƒ€ƒ[ - （OC-（CH 2）m -CO）p - （Pro-Y-Gly）n - ] a€€ƒ€ƒ€ƒ（I）€ƒ€ƒ€ƒ€ ƒ€ƒ€ƒ€ƒ[ - （OC-（CH 2）m -CO）p - （Z）r - ] b€ƒ€ƒ€ƒ€ƒ（II）€ƒ€ƒ€ƒ€ ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ（III）其中m，p，q，Y，n，Z，r，R，a ，b和c如说明书中所定义。 本发明的复合材料由于其生物相容性高，耐久性和机械强度高而特别适用于人造骨。 此外，本发明可以提供根据本发明的复合材料的方法，其可以通过简单的方法制备具有优异机械特性的复合材料。