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    METHODS AND SYSTEMS FOR PROTEIN IDENTIFICATION
    2.
    发明公开
    METHODS AND SYSTEMS FOR PROTEIN IDENTIFICATION 审中-公开

    公开(公告)号：EP4372383A3

    公开(公告)日：2024-11-06

    申请号：EP24169318.3

    申请日：2018-10-20

    申请人： Nautilus Subsidiary, Inc.

    发明人： PATEL, Sujal M. ,  MALLICK, Parag

    IPC分类号： G16B35/20 ,  C40B30/04 ,  G01N33/53 ,  G01N33/68

    摘要： Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for iteratively identifying candidate proteins within a sample of unknown proteins, the method comprising receiving information of binding measurements of each of a plurality of affinity reagent probes to the unknown proteins, each affinity reagent probe configured to selectively bind to one or more candidate proteins; comparing at least a portion of the information of binding measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein; and iteratively generating a probability that each of one or more candidate proteins is present in the sample based on the comparison of the information of binding measurements of the candidate proteins against the database comprising the plurality of protein sequences.

    METHODS OF ASSAYING PROTEINS
    3.
    发明公开
    METHODS OF ASSAYING PROTEINS 审中-实审

    公开(公告)号：EP4365597A3

    公开(公告)日：2024-08-21

    申请号：EP24163221.5

    申请日：2017-12-01

    申请人： Nautilus Subsidiary, Inc.

    发明人： MALLICK, Parag

    IPC分类号： C40B30/04 ,  G01N33/48 ,  G01N33/53 ,  G01N33/68

    CPC分类号： C40B30/04 ,  G01N33/54353 ,  G01N33/6803

    摘要： Methods and systems for identifying a protein within a sample are provided herein. A panel of antibodies are acquired, none of which are specific for a single protein or family of proteins. Additionally, the binding properties of the antibodies in the panel are determined. Further, the protein is iteratively exposed to a panel of antibodies. Additionally, a set of antibodies which bind the protein are determined. The identity of the protein is determined using one or more deconvolution methods based on the known binding properties of the antibodies to match the set of antibodies to a sequence of a protein.

    METHODS OF ASSAYING PROTEINS
    4.
    发明公开
    METHODS OF ASSAYING PROTEINS 审中-实审

    公开(公告)号：EP4365597A2

    公开(公告)日：2024-05-08

    申请号：EP24163221.5

    申请日：2017-12-01

    申请人： Nautilus Subsidiary, Inc.

    发明人： MALLICK, Parag

    IPC分类号： G01N33/68

    CPC分类号： C40B30/04 ,  G01N33/54353 ,  G01N33/6803

    摘要： Methods and systems for identifying a protein within a sample are provided herein. A panel of antibodies are acquired, none of which are specific for a single protein or family of proteins. Additionally, the binding properties of the antibodies in the panel are determined. Further, the protein is iteratively exposed to a panel of antibodies. Additionally, a set of antibodies which bind the protein are determined. The identity of the protein is determined using one or more deconvolution methods based on the known binding properties of the antibodies to match the set of antibodies to a sequence of a protein.