公开(公告)号：EP2692348A1

公开(公告)日：2014-02-05

申请号：EP12765909.2

申请日：2012-03-22

申请人： Neochemir, Inc. ,  CO2BE Medical Engineering K.K. ,  National University Corporation Kobe University

发明人： AKISUE, Toshihiro ,  MIWA, Masahiko ,  UEHA, Takeshi ,  TANAKA, Masaya

IPC分类号： A61K33/00 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00

CPC分类号： A61K33/00 ,  A61K9/00

摘要： An antitumor agent comprising carbon dioxide as an active ingredient of the present invention can reduce the tumor volume or eradicate the tumor of a patient who is difficult to take a surgical therapy, a chemotherapy, a radiation therapy or an immunotherapy. The antitumor agent comprising carbon dioxide as an active ingredient of the present invention is useful because the agent enables (1) the reduction in size or elimination of a tumor, (2) the suppression of tumor metastasis and also (3) the reduction in volume or elimination of a tumor at a part different from the part where carbon dioxide is transdermally absorbed by the transdermal absorption of carbon dioxide through the skin near the tumor or the skin far from the tumor. When the antitumor agent comprising carbon dioxide as an active ingredient of the present invention is used in combination with a surgical therapy, a chemotherapy, a radiation therapy or an immunotherapy, the effect can be potentiated or side effects can be reduced as compared with a monotherapy or a multidisciplinary therapy thereof

摘要翻译： 包含二氧化碳作为本发明活性成分的抗肿瘤剂可减少肿瘤体积或根除难以进行手术治疗，化学疗法，放射疗法或免疫疗法的患者的肿瘤。 本发明的含有二氧化碳作为有效成分的抗肿瘤剂是有用的，因为该试剂能够（1）减小肿瘤尺寸或消除肿瘤，（2）抑制肿瘤转移并且还（3）体积减少 或在二氧化碳透皮吸收通过肿瘤附近的皮肤或远离肿瘤的皮肤透皮吸收二氧化碳透皮吸收部位的部位消除肿瘤。 当将包含二氧化碳作为本发明活性成分的抗肿瘤剂与手术疗法，化学疗法，放射疗法或免疫疗法结合使用时，与单一疗法相比，可以增强效果或减少副作用 或其多学科疗法