公开(公告)号：EP1984013A2

公开(公告)日：2008-10-29

申请号：EP07762625.7

申请日：2007-02-01

申请人： Neose Technologies, Inc.

发明人： JOHNSON, Karl, F. ,  MOBASSERI, Aliakbar ,  BAI, Xiaomei ,  KINEALY, Kyle

IPC分类号： A61K38/16

CPC分类号： C12N9/1081 ,  C07K14/505

摘要： The present invention provides modified Campylobacter sialyltransferase proteins that exhibit enhanced expression as compared to its unmodified form. Nucleic acids that encode the sialyltransferase proteins are also included, as are methods to produce and use the sialyltransferase proteins.

公开(公告)号：EP1765993A2

公开(公告)日：2007-03-28

申请号：EP05759289.1

申请日：2005-06-03

申请人： Neose Technologies, Inc.

发明人： JOHNSON, Karl F. ,  HAKES, David ,  WEI, Ge ,  LIU, Li ,  SARIBAS, Sami ,  SJOBERG, Eric ,  CLAUSEN, Henrik ,  BENNETT, Eric, Paul ,  MOBASSERI, Aliakbar

IPC分类号： C12N9/10

CPC分类号： C12N9/1081 ,  C07K2319/20 ,  C07K2319/40

摘要： The present invention features compositions and methods related to truncated mutants of ST6GalNAcI. In particular, the invention features truncated human, mouse, and chicken ST6GalNAcI polypeptides. The invention also features nucleic acids encoding such truncated polyeptides, as well as vectors, host cells, expression systems, and methods of expressing and using such polypeptides.