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1.发明授权SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS 有权作为激酶抑制剂的合适的取代PYRROLOPYRAZOLDERIVATE
公开(公告)号：EP1575954B1
公开(公告)日：2016-08-03
申请号：EP03799536.2
申请日：2003-12-04
发明人： BRASCA, Maria, Gabriella , AMICI, Raffaella , FANCELLI, Daniele , NESI, Marcella , ORSINI, Paolo , ORZI, Fabrizio , ROUSSEL, Patrick , VULPETTI, Anna , PEVARELLO, Paolo
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
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2.发明公开COMBINATIONS COMPRISING A CDK INHIBITOR AND A GROWTH FACTOR ANTIBODY OR ANTI-MITOTIC 有权WITH A CDK抑制剂和一个WACHSTUMSFAKTORANTIKÖPRER或抗有丝分裂组合
公开(公告)号：EP1986632A1
公开(公告)日：2008-11-05
申请号：EP07726297.0
申请日：2007-02-02
IPC分类号： A61K31/337 , A61K31/519 , A61K39/395 , A61P35/00
CPC分类号： A61K39/395 , A61K31/337 , A61K31/519 , A61K39/39558 , A61K2300/00
摘要： The present invention provides a combination comprising a compound A of formula (I) as set forth in the specification or a pharmaceutically acceptable salt thereof, and an antibody inhibiting a growth factor or its receptor and/or an antimitotic agent or a derivative or prodrug thereof, useful in the treatment of tumors. The chemical name of compound A is 8-[4-(4-methyl-piperazin-1-yl)- phenylamino]-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide.
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公开(公告)号：EP1999131B1
公开(公告)日：2013-10-23
申请号：EP07726618.7
申请日：2007-03-02
发明人： BANDIERA, Tiziano , BERTRAND, Jay Aaron , PEVARELLO, Paolo , PERRONE, Ettore , LOMBARDI BORGIA, Andrea , ORRENIUS, Sten Christian , ANGIOLINI, Mauro , FANCELLI, Daniele
IPC分类号： C07D487/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/496 , A61K31/5377
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4.发明授权COMBINATIONS COMPRISING A CDK INHIBITOR AND A GROWTH FACTOR ANTIBODY OR ANTI-MITOTIC 有权WITH A CDK抑制剂和一个WACHSTUMSFAKTORANTIKÖPRER或抗有丝分裂组合
公开(公告)号：EP1986632B1
公开(公告)日：2012-08-15
申请号：EP07726297.0
申请日：2007-02-02
IPC分类号： A61K31/337 , A61K31/519 , A61K39/395 , A61P35/00
CPC分类号： A61K39/395 , A61K31/337 , A61K31/519 , A61K39/39558 , A61K2300/00
摘要： The present invention provides a combination comprising a compound A of formula (I) as set forth in the specification or a pharmaceutically acceptable salt thereof, and an antibody inhibiting a growth factor or its receptor and/or an antimitotic agent or a derivative or prodrug thereof, useful in the treatment of tumors. The chemical name of compound A is 8-[4-(4-methyl-piperazin-1-yl)- phenylamino]-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide.
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5.发明授权PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权PYRAZOLOCHINAZOLINDERIVATIVE，VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS KINASEINHIBITOREN
公开(公告)号：EP1636236B1
公开(公告)日：2013-10-09
申请号：EP04741483.4
申请日：2004-04-27
发明人： TRAQUANDI, Gabriella , BRASCA, Maria Gabriella , D'ALESSIO, Roberto , POLUCCI, Paolo , ROLETTO, Fulvia , VULPETTI, Anna , PEVARELLO, Paolo , PANZERI, Achille , QUARTIERI, Francesca , FERGUSON, Ron , VIANELLO, Paola , FANCELLI, Daniele
IPC分类号： C07D487/04 , C07D487/14 , A61K31/519 , A61P35/00
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
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公开(公告)号：EP1999131A2
公开(公告)日：2008-12-10
申请号：EP07726618.7
申请日：2007-03-02
发明人： BANDIERA, Tiziano , BERTRAND, Jay Aaron , PEVARELLO, Paolo , PERRONE, Ettore , LOMBARDI BORGIA, Andrea , ORRENIUS, Sten Christian , ANGIOLINI, Mauro , FANCELLI, Daniele
IPC分类号： C07D487/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/496 , A61K31/5377
摘要： A compound having formula (I): wherein: R, A, R1 and R2, are as defined in the specification, and pharmaceutical formulas thereof, and methods of use thereof, as Kinase inhibitors.
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