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    Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
    2.
    发明公开
    Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use 有权
    新的1,4-二氮杂双环[3.2.2]壬基 - 恶二唑基 - 衍生物和衍生物Verwendung

    公开(公告)号：EP2194056A1

    公开(公告)日：2010-06-09

    申请号：EP10154049.0

    申请日：2007-05-29

    申请人： NeuroSearch A/S

    发明人： Peters, Dan ,  Olsen, Gunnar, M. ,  Nielsen, Elsebet, Østergaard ,  Timmermann, Daniel, B. ,  Loechel, Steven, Charles ,  Mikkelsen, Jens, Damsgaard ,  Hansen, Henrik, Björk ,  Redrobe, John, Paul ,  Christensen, Jeppe, Kejser ,  Dyhring, Tino

    IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.
    Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或病症 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。