专利检索 ap:("Neurocrine Biosciences, Inc.") AND inv:"THIELE, William, J." 第 1 页

1.

发明授权
POLYMORPHS OF N-METHYL-N-(3- 3- 2-THIENYLCARBONYL]-PYRAZOL- 1,5-$g(a)]-PYRIMIDIN-7-YL PHENYL)ACETAMIDE AND COMPOSITIONS AND METHODS RELATED THERETO 有权
标题翻译： N-甲基-N-（3-（3- [2-噻吩羰基]吡唑并[1,5-α]嘧啶-7-基）苯基）乙酰胺和组合物和方法相关多晶型物

公开(公告)号：EP1214075B1

公开(公告)日：2004-06-16

申请号：EP00957941.8

申请日：2000-09-01

申请人： Neurocrine Biosciences, Inc.

发明人： THIELE, William, J. , O'DONNELL, Patrick, B.

IPC分类号： A61K31/519 , C07D487/02 , C07D487/04 , A61K31/505

CPC分类号： C07D487/04

摘要： Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide (Compound (1)), and use of the same as a sedative-hypnotic, anxiolytic, anticonvulsant, and skeletal muscle relaxant agent. Processes for making the same, as well as related compositions and methods are also disclosed, particularly with regard to treatment of insomnia. A polymorph Form (I) possessing exception physical and heat stability is provided. A polymorph Form II.

2.

发明公开
POLYMORPHS OF N-METHYL-N-(3- 3- 2-THIENYLCARBONYL]-PYRAZOL- 1,5-$g(a)]-PYRIMIDIN-7-YL PHENYL)ACETAMIDE AND COMPOSITIONS AND METHODS RELATED THERETO 有权
标题翻译： N-甲基-N-（3-（2-噻吩羰基）吡唑并[1,5-a]嘧啶-7-基苯基）乙酰胺和组合物以及方法相关的多晶型

公开(公告)号：EP1214075A1

公开(公告)日：2002-06-19

申请号：EP00957941.8

申请日：2000-09-01

申请人： Neurocrine Biosciences, Inc.

发明人： THIELE, William, J. , O'DONNELL, Patrick, B.

IPC分类号： A61K31/519 , C07D487/02

CPC分类号： C07D487/04

摘要： Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide (Compound (1)), and use of the same as a sedative-hypnotic, anxiolytic, anticonvulsant, and skeletal muscle relaxant agent. Processes for making the same, as well as related compositions and methods are also disclosed, particularly with regard to treatment of insomnia. A polymorph Form (I) possessing exception physical and heat stability is provided. A polymorph Form II.