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1.发明授权DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权双重结合乙酰胆碱酯酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1558255B1
公开(公告)日：2006-12-27
申请号：EP03751019.5
申请日：2003-10-07
申请人： Neuropharma, S.A.
发明人： MARTINEZ GIL, Ana , DORRONSORO DIAZ, Isabel , RUBIO ARRIETA, Laura , ALONSO GORDILLO, Diana , FUERTES HUERTA, Ana , MORALES-ALCELAY, Susana , DEL MONTE MILLAN, Maria , GARCIA PALOMERO, Esther , USAN EGEA, Paola , DE AUSTRIA, Celia , MEDINA PADILLA, Miguel
IPC分类号： A61K31/473 , C07D219/12 , C07D401/12 , C07D417/12
CPC分类号： C07D401/12 , C07D219/12 , C07D417/12
摘要： A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile dementia, cerebrovascular dementia, mild cognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimer’s disease, Parkinson disease, ALS, or prion diseases, as Creutzfeldt-Jakob disease or Gerstmann-Straussler-Scheinher disease.
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2.发明公开DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权双重结合乙酰胆碱酯酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1558255A2
公开(公告)日：2005-08-03
申请号：EP03751019.5
申请日：2003-10-07
申请人： Neuropharma, S.A.
发明人： MARTINEZ GIL, Ana , DORRONSORO DIAZ, Isabel , RUBIO ARRIETA, Laura , ALONSO GORDILLO, Diana , FUERTES HUERTA, Ana , MORALES-ALCELAY, Susana , DEL MONTE MILLAN, Maria , GARCIA PALOMERO, Esther , USAN EGEA, Paola , DE AUSTRIA, Celia , MEDINA PADILLA, Miguel
IPC分类号： A61K31/473 , C07D219/12 , C07D401/12 , C07D417/12
CPC分类号： C07D401/12 , C07D219/12 , C07D417/12
摘要： A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile dementia, cerebrovascular dementia, mild cognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimer’s disease, Parkinson disease, ALS, or prion diseases, as Creutzfeldt-Jakob disease or Gerstmann-Straussler-Scheinher disease.
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