公开(公告)号：EP3080161A2

公开(公告)日：2016-10-19

申请号：EP14869703.0

申请日：2014-12-09

申请人： New York University ,  Janssen Biotech, Inc.

发明人： TORRES, Victor J. ,  BREZSKI, Randall J. ,  LYNCH, Anthony ,  STROHL, William ,  WHITAKER, Brian ,  CHIU, Mark ,  BUCKLEY, Peter T. ,  SORING, Keri ,  KINDER, Michelle

IPC分类号： C07K16/12 ,  G01N33/569

CPC分类号： C07K16/1271 ,  C07K14/78 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2318/00 ,  C07K2319/70 ,  G01N33/56938 ,  G01N2469/10

摘要： The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.

公开(公告)号：EP4216982A2

公开(公告)日：2023-08-02

申请号：EP21873641.1

申请日：2021-09-28

申请人： Janssen Pharmaceuticals, Inc. ,  New York University

发明人： MORROW, Brian ,  KONSTANTINOV, Sergey ,  GEURTSEN, Jeroen ,  LUO, Jinquan ,  SOMANI, Sandeep ,  BUCKLEY, Peter T. ,  TORRES, Victor J.

IPC分类号： A61K38/16 ,  C07K14/31 ,  A61K39/085 ,  C07K16/12 ,  A61K39/40 ,  G01N33/68