公开(公告)号：EP4442285A1

公开(公告)日：2024-10-09

申请号：EP22901284.4

申请日：2022-11-29

申请人： Nihon Medi-Physics Co., Ltd.

发明人： ICHIKAWA, Hiroaki ,  NAKAMURA, Shunsuke ,  TSUSHIMA, Michihiko ,  SATO, Takumi ,  KISHIMOTO, Satoshi ,  OTSUKA, Yuta

IPC分类号： A61K51/08 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/36 ,  A61P43/00

CPC分类号： A61P43/00 ,  A61K47/20 ,  A61K51/08 ,  A61K47/36 ,  A61K51/121

摘要： An object of the present invention is to provide a stable radiopharmaceutical composition in which the decrease in the radiochemical purity over time is suppressed even in the case where the radioactivity concentration is high immediately after production.
The present invention related to a stabilized radiopharmaceutical composition comprising a polypeptide labeled with a radionuclide and having a group selected from the group consisting of a thioether group and a thiol group, as an active ingredient,
a solubilizing agent having an ethylene glycol group,
a solvent comprising water, and
a stabilizer selected from the group consisting of a sulfur-containing amino acid or a salt thereof, a sulfur-containing amino acid derivative or a salt thereof, and a polysaccharide.