公开(公告)号：EP3409291A1

公开(公告)日：2018-12-05

申请号：EP17744444.5

申请日：2017-01-27

申请人： Nissan Chemical Corporation ,  Kyushu University, National University Corporation

发明人： ONO, Fumiyasu ,  GOTO, Masahiro ,  HIRATA, Osamu ,  IWAMA, Takehisa

IPC分类号： A61K47/08 ,  A61K9/08 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K47/44

CPC分类号： A61K9/08 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K47/44

摘要： The present invention addresses the problem of providing a method for increasing the transdermal absorption of a water-soluble drug in a simple manner without relying on the formation of a prodrug of the water-soluble drug by organic synthesis. The present invention relates to: a complex which is formed from a water-soluble active ingredient and a fat-soluble compound having an aldehyde group through an interaction capable of being dissociated in water; a transdermally absorbable composition comprising the complex, a transdermal absorption controlling agent and a fat-soluble medium; and a method for controlling the release of the water-soluble active ingredient from the complex in skin.

公开(公告)号：EP2824157B1

公开(公告)日：2020-02-12

申请号：EP13757549.4

申请日：2013-03-08

申请人： Kyushu University ,  Institute of Systems, Information Technologies and Nanotechnologies ,  Nissan Chemical Corporation

发明人： ONO, Fumiyasu ,  SHINKAI, Seiji ,  HIRATA, Osamu

IPC分类号： C09K3/00 ,  A61K8/60 ,  A61K47/26 ,  C07H9/04 ,  C12N1/00 ,  A61Q19/00 ,  A61K8/04 ,  C07H15/04 ,  H01M10/052 ,  H01M10/0565 ,  H01B1/12