公开(公告)号：EP1855688A2

公开(公告)日：2007-11-21

申请号：EP06735863.0

申请日：2006-02-24

申请人： Nitromed, Inc.

发明人： GARVEY, David, S. ,  LETTS, Gordon, L. ,  EARL, Richard, A. ,  Ezawa, Maiko ,  FANG, Xinqin ,  Gaston, Ricky D. ,  KHANAPURE, Subhash, P. ,  LIN, Chia-En ,  RANATUNGE, Ramani, R. ,  STEVENSON, Cheri, A. ,  Wey, Shiow-Jyi

IPC分类号： A61K31/549 ,  C07D417/02

CPC分类号： C07D285/30 ,  C07D285/28 ,  C07D285/32 ,  C07D417/04 ,  C07D417/06 ,  C07D513/10

摘要： The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; (1) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; (p) treating metabolic syndrome; (q) treating sexual dysfunctions; and (r) hyperlipidemia. The nitric oxide enhancing diuretic compounds comprise at least one nitric oxide enhancing group linked to the diuretic compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.