公开(公告)号：EP2120987B1

公开(公告)日：2014-01-15

申请号：EP08726313.3

申请日：2008-02-29

申请人： NoNO Inc.

发明人： BELMARES, Michael, P. ,  GARMAN, Jonathan, David ,  LU, Peter, S. ,  SALTER, Michael, W. ,  TYMIANSKI, Michael

IPC分类号： A61K38/00 ,  A61K38/04 ,  A61K38/10 ,  A61K38/16 ,  C07K14/435

CPC分类号： A61K47/48246 ,  A61K38/00 ,  A61K47/645 ,  C07K7/06 ,  C07K14/70571 ,  C07K2319/10

公开(公告)号：EP2120987A1

公开(公告)日：2009-11-25

申请号：EP08726313.3

申请日：2008-02-29

申请人： Arbor Vita Corporation ,  Nono Inc.

发明人： BELMARES, Michael, P. ,  GARMAN, Jonathan, David ,  LU, Peter, S. ,  SALTER, Michael, W. ,  TYMIANSKI, Michael

IPC分类号： A61K38/00 ,  A61K38/04 ,  A61K38/10 ,  A61K38/16 ,  C07K14/435

CPC分类号： A61K47/48246 ,  A61K38/00 ,  A61K47/645 ,  C07K7/06 ,  C07K14/70571 ,  C07K2319/10

摘要： The invention provides methods for treating stroke and compositions for use in the same. The methods employ a chimeric peptide pf an active peptide and an internalization peptide. The internalization peptide is a tat variant that promotes uptake of itself and a linked active peptide into a cell without substantial binding to N-type calcium channels. Use of the tat variant allows treating of stroke free of certain side effects associated with binding to N-type calcium channels. Tat variant peptides can also be linked to other active agent for use in treating other diseases.