公开(公告)号：EP2022494A3

公开(公告)日：2009-05-27

申请号：EP08020742.6

申请日：2000-10-18

申请人： Norgine BV ,  President and Fellows of Harvard College

发明人： Barras, Norman ,  Hechtman, Herbert, B.

IPC分类号： A61K31/198 ,  A61P1/10 ,  A61K9/00

CPC分类号： A61K31/198 ,  A61K9/0031

摘要： The invention relates to L-arginine, a derivative thereof or a pharmaceutically acceptable salt thereof for use as a laxative, for treatment of constipation and for clearing the rectum and/or the colon of a mammal. Compositions suitable for topical administration to an area of the gastrointestinal tract are provided. Orally administered preparations comprising for example an enteric coating that dissolves at a desired location in the gastrointestinal tract; a controlled release formulation; a sustained release formulation; a targeted drug delivery system; or a combination thereof are also provided.

公开(公告)号：EP2022494A2

公开(公告)日：2009-02-11

申请号：EP08020742.6

申请日：2000-10-18

申请人： Norgine BV ,  President and Fellows of Harvard College

发明人： Barras, Norman ,  Hechtman, Herbert, B.

IPC分类号： A61K31/198 ,  A61P1/10

CPC分类号： A61K31/198 ,  A61K9/0031

摘要： The invention relates to L-arginine, a derivative thereof or a pharmaceutically acceptable salt thereof for use as a laxative, for treatment of constipation and for clearing the rectum and/or the colon of a mammal. Compositions suitable for topical administration to an area of the gastrointestinal tract are provided. Orally administered preparations comprising for example an enteric coating that dissolves at a desired location in the gastrointestinal tract; a controlled release formulation; a sustained release formulation; a targeted drug delivery system; or a combination thereof are also provided.

摘要翻译： 本发明涉及L-精氨酸，其衍生物或其药学上可接受的盐用作缓泻剂，用于治疗便秘和清除哺乳动物的直肠和/或结肠。 提供了适用于局部施用于胃肠道区域的组合物。 口服给药制剂，其包含例如在胃肠道中的期望位置溶解的肠溶包衣; 控释制剂; 缓释制剂; 有针对性的药物输送系统; 或者它们的组合。