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公开(公告)号：EP2638394A1
公开(公告)日：2013-09-18
申请号：EP11839316.4
申请日：2011-11-14
IPC分类号： G01N33/53 , C07K16/18 , C07K16/30 , G01N33/574
CPC分类号： G01N33/6893 , G01N33/57484 , G01N2440/36 , G01N2500/02
摘要： The present disclosure relates generally to the field of cancer diagnosis. More specifically, the present disclosure relates to the identification and use of monoubiquitination of histone 2B as a biomarker for the diagnosis and prognosis of cancer including, but not limited to, parathyroid cancer. The present disclosure also relates to the identification of binding between CDC73 and RNF20, and the use of CDC73 and RNF20 in an assay for screening for an agent that modulates monoubiquitination of a histone protein.
摘要翻译： 本公开一般涉及癌症诊断领域。 更具体地，本公开涉及组蛋白2B的单泛素化作为癌症的诊断和预后的生物标志物的鉴定和用途，所述癌症包括但不限于甲状旁腺癌。 本公开还涉及CDC73和RNF20之间的结合的鉴定以及CDC73和RNF20在用于筛选调节组蛋白的单泛素化的药剂的测定中的用途。
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公开(公告)号：EP2638394B1
公开(公告)日：2017-05-10
申请号：EP11839316.4
申请日：2011-11-14
IPC分类号： G01N33/53 , C07K16/18 , C07K16/30 , G01N33/574
CPC分类号： G01N33/6893 , G01N33/57484 , G01N2440/36 , G01N2500/02
摘要： The present disclosure relates generally to the field of cancer diagnosis. More specifically, the present disclosure relates to the identification and use of monoubiquitination of histone 2B as a biomarker for the diagnosis and prognosis of cancer including, but not limited to, parathyroid cancer. The present disclosure also relates to the identification of binding between CDC73 and RNF20, and the use of CDC73 and RNF20 in an assay for screening for an agent that modulates monoubiquitination of a histone protein.
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