Lantibiotic biosynthetic gene clusters from A. garbadinensis and A. liguriae
    1.
    发明公开
    Lantibiotic biosynthetic gene clusters from A. garbadinensis and A. liguriae 审中-公开
    生物合成栀子甙A.

    公开(公告)号:EP2189472A1

    公开(公告)日:2010-05-26

    申请号:EP10000424.1

    申请日:2007-01-17

    IPC分类号: C07K7/08 C07K14/365

    CPC分类号: C07K14/365 C12R1/045

    摘要: This invention relates to characterisation of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced according to this invention, utilizing genes from the characterised biosynthetic gene clusters.

    摘要翻译: 本发明涉及生物合成基因簇的表征,其用于拉长肽抗生素,识别阿卡单抗及其生物合成簇的新变体,以及生产和使用阿格达肽的方法,一种新颖的阿格达肽变体,本文中称为卡那加丁B,以及变异体 根据本发明产生的这两者,利用来自特征性生物合成基因簇的基因。