公开(公告)号：EP2847221B1

公开(公告)日：2018-06-20

申请号：EP13742049.3

申请日：2013-05-08

申请人： Novartis AG

发明人： BROWN, Zarin ,  BRADLEY, Michelle ,  CHARLTON, Steven John ,  VAN HEEKE, Gino Anselmus ,  CROMIE, Karen ,  DOMBRECHT, Bruno ,  STEFFENSEN, Soren ,  BAUMEISTER, Judith ,  BOUCHE, Marie-Paule ,  BOUTTON, Carlo ,  BUYSE, Marie-Ange ,  SNOECK, Veerle ,  STAELENS, Stephanie

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K16/468 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/31

摘要： The present invention relates to polypeptides directed against or specifically binding to CXC chemokine receptor 2 (“CXCR2”) and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

公开(公告)号：EP2847221A2

公开(公告)日：2015-03-18

申请号：EP13742049.3

申请日：2013-05-08

申请人： Novartis AG

发明人： BROWN, Zarin ,  BRADLEY, Michelle ,  CHARLTON, Steven John ,  VAN HEEKE, Gino Anselmus ,  CROMIE, Karen ,  DOMBRECHT, Bruno ,  STEFFENSEN, Soren ,  BAUMEISTER, Judith ,  BOUCHE, Marie-Paule ,  BOUTTON, Carlo ,  BUYSE, Marie-Ange ,  SNOECK, Veerle ,  STAELENS, Stephanie

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K16/468 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/31

摘要： The present invention relates to polypeptides directed against or specifically binding to CXC chemokine receptor 2 (“CXCR2”) and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

摘要翻译： 本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2的信号转导的多肽。 本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含所述多肽的药物组合物以及所述多肽和组合物用于治疗涉及CXCR2异常功能的疾病的用途。