公开(公告)号：EP3725805A1

公开(公告)日：2020-10-21

申请号：EP20157418.3

申请日：2013-09-05

申请人： Novartis AG

发明人： BARDROFF, Michael Otto ,  BRANNETTI, Barbara ,  CAMPBELL, Emma Michelle ,  DIEFENBACH-STREIBER, Beate ,  EBERTH, Adina ,  KUNZ, Christian Carsten Silvester ,  MARSHALL, Sylwia ,  RONDEAU, Jean-Michel Rene ,  SCHLAEPPI, Jean-Marc Alfred ,  VAN HEEKE, Gino Anselmus

IPC分类号： C07K16/24 ,  A61K39/395 ,  G01N33/50

摘要： IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

公开(公告)号：EP2892923B1

公开(公告)日：2020-03-25

申请号：EP13792452.8

申请日：2013-09-05

申请人： Novartis AG

发明人： BARDROFF, Michael Otto ,  BRANNETTI, Barbara ,  CAMPBELL, Emma Michelle ,  DIEFENBACH-STREIBER, Beate ,  EBERTH, Adina ,  KUNZ, Christian Carsten Silvester ,  MARSHALL, Sylwia ,  RONDEAU, Jean-Michel Rene ,  SCHLAEPPI, Jean-Marc Alfred ,  VAN HEEKE, Gino Anselmus

IPC分类号： C07K16/24 ,  A61K39/395 ,  G01N33/50

公开(公告)号：EP2892923A2

公开(公告)日：2015-07-15

申请号：EP13792452.8

申请日：2013-09-05

申请人： Novartis AG

发明人： BARDROFF, Michael Otto ,  BRANNETTI, Barbara ,  CAMPBELL, Emma Michelle ,  DIEFENBACH-STREIBER, Beate ,  EBERTH, Adina ,  KUNZ, Christian Carsten Silvester ,  MARSHALL, Sylwia ,  RONDEAU, Jean-Michel Rene ,  SCHLAEPPI, Jean-Marc Alfred ,  VAN HEEKE, Gino Anselmus

IPC分类号： C07K16/24 ,  A61K39/395 ,  G01N33/50

摘要： Interleukin 18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

摘要翻译： 白介素18（IL-18）参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白（IL18BP）（天然存在和高度特异性抑制剂）的负调控。 该可溶性蛋白质与游离IL-18形成复合物，防止其与IL-18受体的相互作用，从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP（IL-18 / IL-18BP复合物）的IL-18的结合分子，特别是抗体或其片段。 除了其生理作用，IL-18已被证明可以介导各种自身免疫性和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子，或作为用于表征，检测和/或测定IL-18BP未结合的IL-18作为总IL的组分的诊断工具 -18游泳池。