公开(公告)号：EP3082877A2

公开(公告)日：2016-10-26

申请号：EP14835606.6

申请日：2014-12-17

申请人： Novartis AG

发明人： GEIERSTANGER, Bernhard ,  GRUNEWALD, Jan ,  OU, Weijia ,  UNO, Tetsuo ,  WAN, Yongqin ,  WANG, Xing ,  JIN, Yunho

IPC分类号： A61K47/48 ,  C07K5/02

CPC分类号： C07K5/0205 ,  A61K47/6817 ,  A61K47/6851 ,  C07K7/02 ,  C07K16/32

摘要： and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

公开(公告)号：EP3154997B1

公开(公告)日：2020-02-19

申请号：EP15732439.3

申请日：2015-06-11

申请人： Novartis AG

发明人： GEIERSTANGER, Bernhard ,  GRUNEWALD, Jan ,  OU, Weijia ,  PAN, Shifeng ,  UNO, Tetsuo ,  WAN, Yongqin ,  WANG, Xing

IPC分类号： C07K5/02 ,  A61K47/68 ,  A61P35/00

公开(公告)号：EP3082877B1

公开(公告)日：2019-08-28

申请号：EP14835606.6

申请日：2014-12-17

申请人： Novartis AG

发明人： GEIERSTANGER, Bernhard ,  GRUNEWALD, Jan ,  OU, Weijia ,  UNO, Tetsuo ,  WAN, Yongqin ,  WANG, Xing ,  JIN, Yunho

IPC分类号： A61K47/50 ,  C07K5/02

公开(公告)号：EP3154997A1

公开(公告)日：2017-04-19

申请号：EP15732439.3

申请日：2015-06-11

申请人： Novartis AG

发明人： GEIERSTANGER, Bernhard ,  GRUNEWALD, Jan ,  OU, Weijia ,  PAN, Shifeng ,  UNO, Tetsuo ,  WAN, Yongqin ,  WANG, Xing

IPC分类号： C07K5/02 ,  A61K47/50

摘要： and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

摘要翻译： 并且这样的肽在制备免疫偶联物中的用途（即抗体药物偶联物）本文还描述了包含与抗原结合部分如抗体连接的新化合物的免疫偶联物（即抗体药物偶联物） 其中这种免疫缀合物可用于治疗细胞增殖性疾病。 本发明还提供包含这些免疫缀合物的药物组合物，包含免疫偶联物与治疗性助剂的组合物，以及使用这些免疫缀合物和组合物治疗细胞增殖障碍的方法。