公开(公告)号：EP2931282A1

公开(公告)日：2015-10-21

申请号：EP13826612.7

申请日：2013-12-12

申请人： Novartis AG

发明人： JACOBY, Edgar ,  REINHARDT, Juergen ,  SCHMIEDEBERG, Niko ,  SPANKA, Carsten

IPC分类号： A61K31/513 ,  C07D471/04 ,  A61P21/00 ,  A61P7/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61K31/519 ,  C07D471/04 ,  C07D471/14

摘要： The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

摘要翻译： 本发明涉及式（I）的化合物; 或其盐，其中取代基如说明书中所定义; 其制备，其作为药物的用途和包含它的药物。

公开(公告)号：EP1836163A2

公开(公告)日：2007-09-26

申请号：EP05825434.3

申请日：2005-12-21

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BREITENSTEIN, Werner ,  COTTENS, Sylvain ,  EHRHARDT, Claus ,  JACOBY, Edgar ,  LORTHIOIS, Edwige, Liliane, Jeanne ,  MAIBAUM, Juergen, Klaus ,  OSTERMANN, Nils ,  SELLNER, Holger ,  SIMIC, Oliver

IPC分类号： C07D207/09 ,  C07D207/14 ,  C07D401/12 ,  C07D405/12 ,  C07D403/12 ,  C07D409/12 ,  C07D207/08 ,  C07D413/12 ,  C07D417/12 ,  C07D491/10 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/54 ,  A61P9/00

CPC分类号： C07D207/08 ,  C07D207/09 ,  C07D207/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/10

摘要： Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel inter­mediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I), wherein the substituents are as described in the specificacion.

公开(公告)号：EP2931282B1

公开(公告)日：2018-10-31

申请号：EP13826612.7

申请日：2013-12-12

申请人： Novartis AG

发明人： JACOBY, Edgar ,  REINHARDT, Juergen ,  SCHMIEDEBERG, Niko ,  SPANKA, Carsten

IPC分类号： A61K31/513 ,  C07D471/04 ,  A61P21/00 ,  A61P7/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61K31/519 ,  C07D471/04 ,  C07D471/14

摘要： The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

公开(公告)号：EP2516009A1

公开(公告)日：2012-10-31

申请号：EP10792944.0

申请日：2010-12-21

申请人： Novartis AG

发明人： BERGHAUSEN, Joerg ,  BUSCHMANN, Nicole ,  FURET, Pascal ,  GESSIER, François ,  HERGOVICH LISZTWAN, Joanna ,  HOLZER, Philipp ,  JACOBY, Edgar ,  KALLEN, Joerg ,  MASUYA, Keiichi ,  PISSOT SOLDERMANN, Carole ,  REN, Haixia ,  STUTZ, Stefan

IPC分类号： A61P35/00 ,  A61K31/495 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D405/14 ,  C07D413/14 ,  C07D217/24

CPC分类号： C07D239/82 ,  C07D217/24 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I): wherein Z is CH
2 or N-R
4 and X, R
1 , R
2 , R
4 , R
6 , R
7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

公开(公告)号：EP2516009B1

公开(公告)日：2014-09-24

申请号：EP10792944.0

申请日：2010-12-21

申请人： Novartis AG

发明人： BERGHAUSEN, Joerg ,  BUSCHMANN, Nicole ,  FURET, Pascal ,  GESSIER, François ,  HERGOVICH LISZTWAN, Joanna ,  HOLZER, Philipp ,  JACOBY, Edgar ,  KALLEN, Joerg ,  MASUYA, Keiichi ,  PISSOT SOLDERMANN, Carole ,  REN, Haixia ,  STUTZ, Stefan

IPC分类号： A61P35/00 ,  A61K31/495 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D405/14 ,  C07D413/14 ,  C07D217/24

CPC分类号： C07D239/82 ,  C07D217/24 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

公开(公告)号：EP1907359A2

公开(公告)日：2008-04-09

申请号：EP06762515.2

申请日：2006-07-10

申请人： Novartis AG

发明人： BREITENSTEIN, Werner ,  EHRHARDT, Claus ,  MAIBAUM, Juergen, Klaus ,  OSTERMANN, Nils ,  ZIMMERMANN, Juerg ,  MASUYA, Keiichi ,  KONISHI, Kazuhide ,  YOKOKAWA, Fumiaki ,  KANAZAWA, Takanori ,  JACOBY, Edgar ,  MARZINZIK, Andreas ,  GROSCHE, Philipp ,  KAWAKAMI, Shimpei

IPC分类号： C07D211/56 ,  C07D409/12 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  C07D413/14 ,  C07D403/14 ,  A61K31/55 ,  A61P9/00

CPC分类号： C07D403/14 ,  C07D211/56 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3, 5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1 , R2, T, R3 and R4 are as defined in the specification.

公开(公告)号：EP1836163B1

公开(公告)日：2010-09-22

申请号：EP05825434.3

申请日：2005-12-21

申请人： Novartis AG

发明人： BREITENSTEIN, Werner ,  COTTENS, Sylvain ,  EHRHARDT, Claus ,  JACOBY, Edgar ,  LORTHIOIS, Edwige, Liliane, Jeanne ,  MAIBAUM, Juergen, Klaus ,  OSTERMANN, Nils ,  SELLNER, Holger ,  SIMIC, Oliver

IPC分类号： C07D207/09 ,  C07D207/14 ,  C07D401/12 ,  C07D405/12 ,  C07D403/12 ,  C07D409/12 ,  C07D207/08 ,  C07D413/12 ,  C07D417/12 ,  C07D491/10 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/54 ,  A61P9/00

CPC分类号： C07D207/08 ,  C07D207/09 ,  C07D207/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/10

摘要： Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel inter­mediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I), wherein the substituents are as described in the specificacion.