公开(公告)号：EP2625203A1

公开(公告)日：2013-08-14

申请号：EP11766979.6

申请日：2011-10-03

申请人： Novartis AG

发明人： CARBALLIDO HERRERA, José M. ,  HARTLE, Stefan ,  HEUSSER, Christoph ,  KLAGGE, Ingo ,  POLZER, Andrea ,  SCHWAERZLER, Christoph ,  WOCHNIK-VELTRUP, Gabriela

IPC分类号： C07K16/28

CPC分类号： C12N9/0069 ,  C07K16/2866 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/66

摘要： The present invention relates to antibodies that specifically bind to IL12Rβ1, the non- signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFN
Ƴ production of blood cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFN
Ƴ production, IL12 and/IL23 signaling, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.