-
公开(公告)号：EP1784399B1
公开(公告)日：2011-06-15
申请号：EP05782820.4
申请日：2005-08-26
申请人： Novartis AG
发明人： KAWAHARA, Eiji, Novartis Pharma K.K. , MIYAKE, Takahiro, Novartis Pharma K.K. , ROESEL, Johannes
IPC分类号： C07D403/12 , C07D403/14 , C07D498/04 , A61P35/00 , A61P37/00 , A61K31/506
CPC分类号： C07D239/48 , C07D401/14 , C07D403/12 , C07D403/14
摘要： Novel pyrimidine derivatives of formula (I) to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
-
公开(公告)号：EP1784399A2
公开(公告)日：2007-05-16
申请号：EP05782820.4
申请日：2005-08-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： KAWAHARA, Eiji, Novartis Pharma K.K. , MIYAKE, Takahiro, Novartis Pharma K.K. , ROESEL, Johannes
IPC分类号： C07D403/12 , C07D403/14 , C07D498/04 , A61P35/00 , A61P37/00 , A61K31/506
CPC分类号： C07D239/48 , C07D401/14 , C07D403/12 , C07D403/14
摘要： Novel pyrimidine derivatives of formula (I) to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
-
3.发明公开COMBINATION THERAPY CONTAINING A PI3K-ALPHA INHIBITOR AND FGFR KINASE INHIBITOR FOR TREATING CANCER 审中-公开WITH A PI3K-α抑制剂和FGFR激酶抑制剂联合治疗癌症的治疗
公开(公告)号：EP3003377A1
公开(公告)日：2016-04-13
申请号：EP14730592.4
申请日：2014-05-28
申请人： Novartis AG
发明人： FRITSCH, Christine , CHATENAY-RIVAUDAY, Christian , ROESEL, Johannes , WARTMANN, Markus , GRAUS PORTA, Diana
IPC分类号： A61K45/06 , A61K31/4439 , A61K31/506 , A61P35/00
CPC分类号： A61K31/4439 , A61K31/506 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
摘要： A pharmaceutical combination comprising an alpha-isoform specific phosphatidylinositol 3-kinase inhibitor compound of formula (I) or a pharmaceutically acceptable salt thereof and a fibroblast growth factor receptor (FGFR) kinase inhibitor, particularly for simultaneous, separate or sequential use for the treatment of a cancer; use of such pharmaceutical combination for the preparation of a medicament for the treatment of a cancer; use of such pharmaceutical combination for the treatment a cancer; a method for treating a cancer comprising administering to a subject having said cancer a jointly therapeutically effective amount of such combination; and related pharmaceutical compositions or kits thereof.
-
4.发明公开COMBINATION COMPRISING A PYRIMIDYLAMINOBENZAMIDES AND A FLT-3 INHIBITOR FOR TREATING PROLIFERATIVE DISEASES 审中-公开PYRIMIDYLAMINOBENZAMIDEN组合AND A FLT-3抑制剂治疗增殖疾病治疗
公开(公告)号：EP1954278A2
公开(公告)日：2008-08-13
申请号：EP06764230.6
申请日：2006-07-19
申请人： Novartis AG
发明人： MANLEY, Paul, W. , ROESEL, Johannes
IPC分类号： A61K31/506 , A61P35/00
CPC分类号： A61K45/06 , A61K31/506 , A61K2300/00
摘要： The invention provides a pharmaceutical combination comprising: a) a pyrimidylaminobenzamide compound; and b) a Flt-3inhibitor, and a method for treating or preventing a proliferative disease using such a combination.
-
公开(公告)号：EP1784392A2
公开(公告)日：2007-05-16
申请号：EP05776772.5
申请日：2005-08-26
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： IMBACH, Patricia , KAWAHARA, Eiji Novartis Pharma K.K. , KONISHI, Kazuhide Novartis Pharma K.K. , MATSUURA, Naoko Novartis Pharma K.K. , MIYAKE, Takahiro Novartis Pharma K.K. , OHMORI, Osamu Novartis Pharma K.K. , ROESEL, Johannes , TENO, Naoki Novartis Pharma K.K. , UMEMURA, Ichiro Novartis Pharma K.K.
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D403/14 , C07D401/14 , C07D498/04 , C07D409/12 , C07D409/14 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D413/12
摘要： Novel pyrimidine derivatives of formula (I) to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 式（I）的新型嘧啶衍生物用于其生产的方法，其作为药物的用途以及包含它们的药物组合物。
-
6.发明公开DIARYL UREA DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 审中-公开蛋白激酶依赖性疾病治疗的二芳基脲衍生物
公开(公告)号：EP1689376A2
公开(公告)日：2006-08-16
申请号：EP04798101.4
申请日：2004-11-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLD, Guido , CARAVATTI, Giorgio , FLOERSHEIMER, Andreas , GUAGNANO, Vito , IMBACH, Patricia , MASUYA, Keiichi , ROESEL, Johannes , VAUPEL, Andrea , GARCIA-ECHEVERRIA, Carlos
IPC分类号： A61K31/00
CPC分类号： C04B35/632 , C07D239/34 , C07D239/47 , C07D401/12 , C07D403/12
摘要： The invention relates to the use of diaryl urea derivatives for the manufacture of pharmaceutical compositions for the treatment of RET dependent disorders, especially RET dependent tumor diseases. The invention further relates to novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and their use in the treatment of the animal or human body, especially in the treatment of a protein kinase dependent disease, to pharmaceutical compositions comprising such novel N-[4-pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and to the use of such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as tumour diseases.
-
7.发明公开2,4-DI (PHENYLAMINO) PYRIMIDINES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开2,4-二（苯基氨基）嘧啶类所产生增殖性疾病的治疗是合适的
公开(公告)号：EP1663992A1
公开(公告)日：2006-06-07
申请号：EP04765358.9
申请日：2004-09-17
申请人： Novartis AG , Novartis Pharma GmbH
发明人： IMBACH, Patricia , ROESEL, Johannes
IPC分类号： C07D239/48 , C07D405/12 , C07D403/12 , C07D401/12 , C07D401/14 , A61K31/506 , A61K35/00
CPC分类号： C07D403/14 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , C04B35/632 , C07D239/48 , C07D401/12 , C07D403/12
摘要： There is provided a method of preventing or treating proliferative disorders such as a tumor disease, by inhibiting ALK activity with compounds of formula (I) wherein X, R1, R2 , R3 , R4 , R5, R6, R7,R8 and R9 are as indicated in claim 1.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.023 秒)
