公开(公告)号：EP2516458A1

公开(公告)日：2012-10-31

申请号：EP10795387.9

申请日：2010-12-21

申请人： Novartis AG

发明人： HUBER, Thomas ,  KOLBINGER, Frank ,  SARFATI, Marie ,  WELZENBACH, Karl

IPC分类号： C07K14/705 ,  C07K19/00 ,  C07K16/00 ,  A61K39/00 ,  A61P11/06 ,  A61P29/00 ,  A61K38/00

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/70596 ,  C07K2319/30

摘要： The present invention relates to soluble SIRPα binding proteins, for use as a medicament, in particular for the prevention or treatment of autoimmune and inflammatory disorders, for example allergic asthma and inflammatory bowel diseases. The invention more specifically relates to a soluble SIRPα binding protein comprising a complex of two heterodimers, wherein each heterodimer essentially consists of: (i) a first monovalent single chain polypeptide comprising a first SIRPα binding domain fused at the N-terminal part of a heavy chain constant region of an antibody; and, (ii) a second monovalent single chain polypeptide comprising a second SIRPα binding domain fused at the N-terminal part of a CL light chain constant region of an antibody. The invention further relates to soluble SIRPα-binding antibody-like protein as shown in Figure 1.

公开(公告)号：EP2379584A1

公开(公告)日：2011-10-26

申请号：EP09796708.7

申请日：2009-12-17

申请人： Novartis AG

发明人： RAYMOND, Marianne ,  SARFATI, Marie ,  WELZENBACH, Karl ,  WOISETSCHLAEGER, Maximilian

IPC分类号： C07K14/435 ,  A61K38/17 ,  C07K14/705 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  C12N15/68

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： The present invention relates to soluble CD47 binding polypeptides, for use as a medicament, in particular for the prevention or treatment of autoimmune and inflammatory disorders, for example allergic asthma and inflammatory bowel diseases. The Invention more specifically relates to a soluble CD47 binding polypeptide for use as a medicament, comprising an extracellular domain of SIRPα (CD172a) or functional derivatives which bind to human CD47.