公开(公告)号：EP2768813A1

公开(公告)日：2014-08-27

申请号：EP12791859.7

申请日：2012-10-19

申请人： Novartis AG

发明人： FURET, Pascal ,  HEBACH, Christina ,  HÖGENAUER, Klemens ,  HOLLINGWORTH, Gregory ,  LEWIS, Ian ,  SMITH, Alexander, Baxter ,  SOLDERMANN, Nicolas ,  STAUFFER, Frédéric ,  WOLF, Romain ,  ZECRI, Frédéric

IPC分类号： C07D239/74 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D487/08 ,  A61K31/517 ,  A61P37/00 ,  A61P29/00 ,  A61P11/00 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D239/74 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D487/08

摘要： The invention relates to substituted quinazoline derivative of the formula (I), wherein A, X
1 , X
2 , X
3 , X
4 and R
5 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.