公开(公告)号：EP2171059A2

公开(公告)日：2010-04-07

申请号：EP08761002.8

申请日：2008-06-13

申请人： Novartis AG

发明人： VAN HEEKE, Gino ,  HICKMAN, Emma ,  DANAHAY, Henry Luke ,  TAN, Pamela ,  GEICK, Anke ,  VORNLOCHER, Hans-Peter

IPC分类号： C12N15/11 ,  A61K31/713

CPC分类号： C12N15/1138 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2310/3521

摘要： The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.

摘要翻译： 本发明涉及用于调节α-ENaC表达的组合物和方法，更具体地涉及通过化学修饰的寡核苷酸下调α-ENaC表达。

公开(公告)号：EP1999260A2

公开(公告)日：2008-12-10

申请号：EP07753837.9

申请日：2007-03-23

申请人： NOVARTIS AG ,  NOVARTIS-PHARMA GMBH

发明人： BENSON, John ,  BRAMLAGE, Birgit ,  FITZGERALD, Kevin ,  TAN, Pamela ,  VORNLOCHER, Hans-Peter

IPC分类号： C12N15/11 ,  A61K31/713 ,  C07H21/00 ,  A61P31/20

CPC分类号： C12N15/1137 ,  C12N15/111 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2320/31 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.

公开(公告)号：EP2137313A2

公开(公告)日：2009-12-30

申请号：EP08718165.7

申请日：2008-03-25

申请人： Novartis AG ,  Alnylam Pharmaceuticals, Inc

发明人： BENSON, John ,  FITZGERALD, Kevin ,  BRAMLAGE, Birgit ,  TAN, Pamela ,  VORNLOCHER, Hans-Peter

IPC分类号： C12N15/11

CPC分类号： C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12Y603/02019 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.