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公开(公告)号：EP1220852A1
公开(公告)日：2002-07-10
申请号：EP00969490.2
申请日：2000-10-11
申请人： Novartis AG
发明人： ALBERT, Rainer , EHRHARDT, Claus , HOMMEL, Ulrich , KALLEN, Jörg , MEINGASSNER, Josef, Gottfried , ROCHE, Didier , WATTANASIN, Sompong , WEITZ-SCHMIDT, Gabriele , WELZENBACH, Karl
IPC分类号： C07D401/06 , C07D243/08 , A61K31/4709 , A61K31/551
CPC分类号： C07K5/06139 , A61K38/05 , A61K31/00 , A61K2300/00
摘要： The invention provides novel diazepanes having interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1, -ICAM-2 or -ICAM-3 interactions.
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公开(公告)号：EP1154988A1
公开(公告)日：2001-11-21
申请号：EP00916832.9
申请日：2000-02-14
发明人： BAENTELI, Rolf , BAUER, Wilfried , COTTENS, Sylvain , EHRHARDT, Claus , HOMMEL, Ulrich , KALLEN, Jörg , MEINGASSNER, Josef, Gottfried , NUNINGER, François , WEITZ-SCHMIDT, Gabriele
IPC分类号： C07C235/26 , C07C237/18 , C07C235/30 , C07C237/20 , C07D211/76 , C07D265/24 , C07D401/06 , A61K31/4402 , A61K31/45 , A61K31/4545 , A61K31/535 , A61P9/10 , A61P3/06 , A61P29/00 , A61P37/00
CPC分类号： C07C271/12 , C07C235/26 , C07C235/30 , C07C237/18 , C07C2602/28 , C07D211/76 , C07D265/10
摘要： Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions.
摘要翻译： 其中内酯环被改性的美维诺林衍生物具有令人感兴趣的药物性质，特别是在预防或治疗由LFA-1 / ICAM-1相互作用介导的病症或疾病方面。
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公开(公告)号：EP1220852B1
公开(公告)日：2006-01-18
申请号：EP00969490.2
申请日：2000-10-11
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALBERT, Rainer , EHRHARDT, Claus , HOMMEL, Ulrich , KALLEN, Jörg , MEINGASSNER, Josef, Gottfried , ROCHE, Didier , WATTANASIN, Sompong , WEITZ-SCHMIDT, Gabriele , WELZENBACH, Karl
IPC分类号： C07D401/06 , C07D243/08 , A61K31/4709 , A61K31/551
CPC分类号： C07K5/06139 , A61K38/05 , A61K31/00 , A61K2300/00
摘要： The invention provides novel diazepanes having interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1, -ICAM-2 or -ICAM-3 interactions.
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公开(公告)号：EP1007033A1
公开(公告)日：2000-06-14
申请号：EP98951317.1
申请日：1998-08-26
发明人： BAUER, Wilfried , COTTENS, Sylvain , GEYL, Dieter , WEITZ-SCHMIDT, Gabriele , KALLEN, Jörg , HOMMEL, Ulrich
IPC分类号： A61K31/365 , A61K31/22 , A61K31/19 , A61K31/44 , C07D309/10 , C07D309/30 , C07D319/06 , C07D213/64
CPC分类号： C07D213/64 , A61K31/00 , A61K31/222 , A61K31/366 , C07C219/24 , C07C235/30 , C07C237/18 , C07C237/22 , C07C2601/08 , C07C2602/28 , C07D207/16 , C07D295/13 , C07D295/145 , C07D295/205 , C07D307/52 , C07D309/10 , C07D309/30 , C07D405/12 , C07D491/10
摘要： The present invention relates to compounds which bind to all or parts of the active binding 'south pole pocket' of the LFA-1 I-domain and their uses as LFA-1 antagonists.
摘要翻译： 美维林化合物，用于治疗或预防自身免疫疾病，炎症，缺血/再灌注损伤和移植排斥反应。 这样的化合物结合LFA-1 I结构域，从而抑制LFA-1 / ICAM-1或LFA-1 / ICAM-3相互作用。
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公开(公告)号：EP1007033B1
公开(公告)日：2008-04-23
申请号：EP98951317.1
申请日：1998-08-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BAUER, Wilfried , COTTENS, Sylvain , GEYL, Dieter , WEITZ-SCHMIDT, Gabriele , KALLEN, Jörg , HOMMEL, Ulrich
IPC分类号： A61K31/365 , A61K31/22 , A61K31/19 , A61K31/44 , C07D309/10 , C07D309/30 , C07D319/06 , C07D213/64
CPC分类号： C07D213/64 , A61K31/00 , A61K31/222 , A61K31/366 , C07C219/24 , C07C235/30 , C07C237/18 , C07C237/22 , C07C2601/08 , C07C2602/28 , C07D207/16 , C07D295/13 , C07D295/145 , C07D295/205 , C07D307/52 , C07D309/10 , C07D309/30 , C07D405/12 , C07D491/10
摘要： The present invention relates to compounds which bind to all or parts of the active binding 'south pole pocket' of the LFA-1 I-domain and their uses as LFA-1 antagonists.
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公开(公告)号：EP1154988B1
公开(公告)日：2004-08-11
申请号：EP00916832.9
申请日：2000-02-14
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BAENTELI, Rolf , BAUER, Wilfried , COTTENS, Sylvain , EHRHARDT, Claus , HOMMEL, Ulrich , KALLEN, Jörg , MEINGASSNER, Josef, Gottfried , NUNINGER, François , WEITZ-SCHMIDT, Gabriele
IPC分类号： C07C235/26 , C07C237/18 , C07C235/30 , C07C237/20 , C07D211/76 , C07D265/24 , C07D401/06 , A61K31/4402 , A61K31/45 , A61K31/4545 , A61K31/535 , A61P9/10 , A61P3/06 , A61P29/00 , A61P37/00
CPC分类号： C07C271/12 , C07C235/26 , C07C235/30 , C07C237/18 , C07C2602/28 , C07D211/76 , C07D265/10
摘要： Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions.
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