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公开(公告)号：EP2331547B1
公开(公告)日：2014-07-30
申请号：EP09782051.8
申请日：2009-08-20
发明人： BESONG, Gilbert , BRAIN, Christopher Thomas , BROOKS, Clinton A. , CONGREVE, Miles Stuart , DAGOSTIN, Claudio , HE, Guo , HOU, Ying , HOWARD, Steven , LI, Yue , LU, Yipin , MORTENSON, Paul , SMITH, Troy , SUNG, Moo , WOODHEAD, Steven , WRONA, Wojciech , LAGU, Bharat
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , C07D487/08
摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
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公开(公告)号：EP2331547A1
公开(公告)日：2011-06-15
申请号：EP09782051.8
申请日：2009-08-20
发明人： BESONG, Gilbert , BRAIN, Christopher Thomas , BROOKS, Clinton A. , CONGREVE, Miles Stuart , DAGOSTIN, Claudio , HE, Guo , HOU, Ying , HOWARD, Steven , LI, Yue , LU, Yipin , MORTENSON, Paul , SMITH, Troy , SUNG, Moo , WOODHEAD, Steven , WRONA, Wojciech
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , C07D487/08
摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和治疗。 还需要用于治疗或预防或改善癌症，移植排斥和自身免疫疾病的一种或多种症状的化合物。 此外，需要使用本文提供的化合物来调节蛋白激酶例如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。
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